Dr. Rhonda Patrick

It does. And when we have gut permeability, lots of things that cause that, it releases it. Right. Also known as leaky gut. It leaches the LPS into our bloodstream. Well, this study took healthy individuals and injected them with an amount of LPS that would be equivalent to something that you could get from intestinal permeability. And it caused depressive symptoms in these individuals.

Okay, one, that links inflammation to depression, right? 100%. Two, if those individuals were given EPA, so this is one of the omega-3 fatty acids, it does play a major role in dampening inflammation through a variety of mechanisms like resolvins and mericins and the SPMs. These are all molecules that are resolving inflammation very quickly.

Okay, one, that links inflammation to depression, right? 100%. Two, if those individuals were given EPA, so this is one of the omega-3 fatty acids, it does play a major role in dampening inflammation through a variety of mechanisms like resolvins and mericins and the SPMs. These are all molecules that are resolving inflammation very quickly.

Okay, one, that links inflammation to depression, right? 100%. Two, if those individuals were given EPA, so this is one of the omega-3 fatty acids, it does play a major role in dampening inflammation through a variety of mechanisms like resolvins and mericins and the SPMs. These are all molecules that are resolving inflammation very quickly.

They did not experience those depressive symptoms if they were injected with the LPS.

They did not experience those depressive symptoms if they were injected with the LPS.

They did not experience those depressive symptoms if they were injected with the LPS.

If they have the omega-3s. Yeah. So it comes down to like, again, you know... And omega-3s have been shown to actually help with depression. They have.

If they have the omega-3s. Yeah. So it comes down to like, again, you know... And omega-3s have been shown to actually help with depression. They have.

If they have the omega-3s. Yeah. So it comes down to like, again, you know... And omega-3s have been shown to actually help with depression. They have.

Yeah. With depression, specifically EPA seems to be very important for depression. And I think that's because there's a really big inflammatory component to depression where, you know, there's now studies showing that people that don't respond to classical SSRIs, so serotonin reuptake inhibitors...

Yeah. With depression, specifically EPA seems to be very important for depression. And I think that's because there's a really big inflammatory component to depression where, you know, there's now studies showing that people that don't respond to classical SSRIs, so serotonin reuptake inhibitors...

Yeah. With depression, specifically EPA seems to be very important for depression. And I think that's because there's a really big inflammatory component to depression where, you know, there's now studies showing that people that don't respond to classical SSRIs, so serotonin reuptake inhibitors...

Exactly. People that don't respond to that, they typically have very, very high levels of C-reactive protein inflammation. So there's like a subset of people. Some people respond and it helps them. But there's a subset, a quite large subset of people that... that have very high inflammatory biomarkers and do not respond to SSRIs.

Exactly. People that don't respond to that, they typically have very, very high levels of C-reactive protein inflammation. So there's like a subset of people. Some people respond and it helps them. But there's a subset, a quite large subset of people that... that have very high inflammatory biomarkers and do not respond to SSRIs.

Exactly. People that don't respond to that, they typically have very, very high levels of C-reactive protein inflammation. So there's like a subset of people. Some people respond and it helps them. But there's a subset, a quite large subset of people that... that have very high inflammatory biomarkers and do not respond to SSRIs.

And so logically, the next question would be, should we lower their inflammation?

And so logically, the next question would be, should we lower their inflammation?

And so logically, the next question would be, should we lower their inflammation?

I completely, a thousand percent agree. I just made this up. So I think that humans, We evolved to eat plants and meat and things, but plants, because of the phytochemicals. So you mentioned sulforaphane, right? So sulforaphane is present in a variety of cruciferous vegetables like broccoli. It's much more – it's not present – I'm sorry.