Dr. Rhonda Patrick

I completely, a thousand percent agree. I just made this up. So I think that humans, We evolved to eat plants and meat and things, but plants, because of the phytochemicals. So you mentioned sulforaphane, right? So sulforaphane is present in a variety of cruciferous vegetables like broccoli. It's much more – it's not present – I'm sorry.

I completely, a thousand percent agree. I just made this up. So I think that humans, We evolved to eat plants and meat and things, but plants, because of the phytochemicals. So you mentioned sulforaphane, right? So sulforaphane is present in a variety of cruciferous vegetables like broccoli. It's much more – it's not present – I'm sorry.

The precursor to it, glucoraphanin, is present in it, and it gets converted into sulforaphane when the plant matter is broken, chewed, because it activates an enzyme called myrosinase, which converts glucoraphanin into sulforaphane.

The precursor to it, glucoraphanin, is present in it, and it gets converted into sulforaphane when the plant matter is broken, chewed, because it activates an enzyme called myrosinase, which converts glucoraphanin into sulforaphane.

The precursor to it, glucoraphanin, is present in it, and it gets converted into sulforaphane when the plant matter is broken, chewed, because it activates an enzyme called myrosinase, which converts glucoraphanin into sulforaphane.

Exactly. And if you go even further and chew the young plant, the broccoli sprouts, there's about 100 times more glucoraphanin in it.

Exactly. And if you go even further and chew the young plant, the broccoli sprouts, there's about 100 times more glucoraphanin in it.

Exactly. And if you go even further and chew the young plant, the broccoli sprouts, there's about 100 times more glucoraphanin in it.

Yes, broccoli sprouts are really, really high in glucoraphanin. I also take a supplement that's been used in a lot of clinical studies called Avmacol. I don't have any affiliation with them, but they've got a really great method of stabilizing that myrosinase enzyme, which is very unstable. It's also very heat sensitive.

Yes, broccoli sprouts are really, really high in glucoraphanin. I also take a supplement that's been used in a lot of clinical studies called Avmacol. I don't have any affiliation with them, but they've got a really great method of stabilizing that myrosinase enzyme, which is very unstable. It's also very heat sensitive.

Yes, broccoli sprouts are really, really high in glucoraphanin. I also take a supplement that's been used in a lot of clinical studies called Avmacol. I don't have any affiliation with them, but they've got a really great method of stabilizing that myrosinase enzyme, which is very unstable. It's also very heat sensitive.

But before I get sidetracked, sulforaphane is the most potent dietary activator of what's called transcription factor in our body. It's NRF2. And this is... NRF2. Yeah. It's a master regulator of, as you mentioned, detoxification enzymes. So they're called phase two detoxification enzymes. Also phase one biotransformation enzymes.

But before I get sidetracked, sulforaphane is the most potent dietary activator of what's called transcription factor in our body. It's NRF2. And this is... NRF2. Yeah. It's a master regulator of, as you mentioned, detoxification enzymes. So they're called phase two detoxification enzymes. Also phase one biotransformation enzymes.

But before I get sidetracked, sulforaphane is the most potent dietary activator of what's called transcription factor in our body. It's NRF2. And this is... NRF2. Yeah. It's a master regulator of, as you mentioned, detoxification enzymes. So they're called phase two detoxification enzymes. Also phase one biotransformation enzymes.

So those are enzymes that will convert procarcinogens into carcinogens. So NRF2 activation will blunt that. It'll stop that from happening. So think things like nitrites being converted into nitrosamines. Nitrites are present in a lot of processed meats and So Nrf2 activation, typically it's like it gets activated every 80 minutes or so inside of our cells.

So those are enzymes that will convert procarcinogens into carcinogens. So NRF2 activation will blunt that. It'll stop that from happening. So think things like nitrites being converted into nitrosamines. Nitrites are present in a lot of processed meats and So Nrf2 activation, typically it's like it gets activated every 80 minutes or so inside of our cells.

So those are enzymes that will convert procarcinogens into carcinogens. So NRF2 activation will blunt that. It'll stop that from happening. So think things like nitrites being converted into nitrosamines. Nitrites are present in a lot of processed meats and So Nrf2 activation, typically it's like it gets activated every 80 minutes or so inside of our cells.

But if you take sulforaphane, it gets activated every 130 minutes. But if you take sulforaphane, it gets activated like every 80 minutes, something like that, where it's like you're getting like a 60% increase in the activation of this important transcription factor, which is regulating just hundreds of different genes that are antioxidant, involved in antioxidant function, anti-inflammation. Yeah.

But if you take sulforaphane, it gets activated every 130 minutes. But if you take sulforaphane, it gets activated like every 80 minutes, something like that, where it's like you're getting like a 60% increase in the activation of this important transcription factor, which is regulating just hundreds of different genes that are antioxidant, involved in antioxidant function, anti-inflammation. Yeah.

But if you take sulforaphane, it gets activated every 130 minutes. But if you take sulforaphane, it gets activated like every 80 minutes, something like that, where it's like you're getting like a 60% increase in the activation of this important transcription factor, which is regulating just hundreds of different genes that are antioxidant, involved in antioxidant function, anti-inflammation. Yeah.