Dr. Richard Johnson

Yes. You want to reduce the activity there so that you have the self-control is not so strong.

Right. And you got to quiet the recent memory because you don't really want to remember how dangerous it really is, what you're about to do. You don't want to remember that line you saw yesterday. So you want to quiet that. You want to stimulate the visual cues so that you can see things real quickly.

Right. And you got to quiet the recent memory because you don't really want to remember how dangerous it really is, what you're about to do. You don't want to remember that line you saw yesterday. So you want to quiet that. You want to stimulate the visual cues so that you can see things real quickly.

Right. And you got to quiet the recent memory because you don't really want to remember how dangerous it really is, what you're about to do. You don't want to remember that line you saw yesterday. So you want to quiet that. You want to stimulate the visual cues so that you can see things real quickly.

You want to reduce the activity to the areas that are involved in deliberation so that you want to stimulate locomotor activity. So there are some things you want to stimulate and some things you want to inhibit.

You want to reduce the activity to the areas that are involved in deliberation so that you want to stimulate locomotor activity. So there are some things you want to stimulate and some things you want to inhibit.

You want to reduce the activity to the areas that are involved in deliberation so that you want to stimulate locomotor activity. So there are some things you want to stimulate and some things you want to inhibit.

Mm hmm.

Mm hmm.

Mm hmm.

So when you give fructose to a human intravenously or orally, you can do this thing called bold MRI and you can do these different things where you can look at changes in blood flow. You can look at that and guess what? If you give fructose, you activate these foraging responses, you inhibit the cortex, you inhibit blood flow to the hippocampus, which is involved in recent memory.

So when you give fructose to a human intravenously or orally, you can do this thing called bold MRI and you can do these different things where you can look at changes in blood flow. You can look at that and guess what? If you give fructose, you activate these foraging responses, you inhibit the cortex, you inhibit blood flow to the hippocampus, which is involved in recent memory.

So when you give fructose to a human intravenously or orally, you can do this thing called bold MRI and you can do these different things where you can look at changes in blood flow. You can look at that and guess what? If you give fructose, you activate these foraging responses, you inhibit the cortex, you inhibit blood flow to the hippocampus, which is involved in recent memory.

You stimulate the, you know, other areas, you know, like the visual cortex, for cues, for food. And you can show that if you give glucose acutely and you just look in the first 15 minutes. Remember, it takes an hour for the glucose to start converting. So if you look the first 15 minutes, you see the opposite effects of fructose. Glucose is not aiming to make you hungry. It's to satisfy you.

You stimulate the, you know, other areas, you know, like the visual cortex, for cues, for food. And you can show that if you give glucose acutely and you just look in the first 15 minutes. Remember, it takes an hour for the glucose to start converting. So if you look the first 15 minutes, you see the opposite effects of fructose. Glucose is not aiming to make you hungry. It's to satisfy you.

You stimulate the, you know, other areas, you know, like the visual cortex, for cues, for food. And you can show that if you give glucose acutely and you just look in the first 15 minutes. Remember, it takes an hour for the glucose to start converting. So if you look the first 15 minutes, you see the opposite effects of fructose. Glucose is not aiming to make you hungry. It's to satisfy you.

So it's more of a, it's a different... So it turns out that the foraging response requires activation of the anterior cingulate. It's a part of the brain and the occiput. And the anterior cingulate has been uniquely known to be spared in Alzheimer's. And the visual cortex is generally spared.

So it's more of a, it's a different... So it turns out that the foraging response requires activation of the anterior cingulate. It's a part of the brain and the occiput. And the anterior cingulate has been uniquely known to be spared in Alzheimer's. And the visual cortex is generally spared.

So it's more of a, it's a different... So it turns out that the foraging response requires activation of the anterior cingulate. It's a part of the brain and the occiput. And the anterior cingulate has been uniquely known to be spared in Alzheimer's. And the visual cortex is generally spared.

Whereas all the areas that tryptophan inhibits turn out to be the regions of the brain that are specifically targeted in Alzheimer's. I mean, eventually Alzheimer's will affect all the brain, but in the beginning, you can really show this difference. And so when I presented that to Dale and to David Perlmutter, they go,