Dr. Sabine Hazan
speaker
74 appearances
1 recordings
1 series
first heard May 2025
last heard May 2025
Dr. Sabine Hazan’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsNo recordings in the last 12 months.Older appearances are listed below; set an alert to hear about the next one.
Appearances
Yeah, so I'm coming out with a case report and that's really my case report during the pandemic because I was the guinea pig. And so I kind of followed myself through the pandemic. And what I think happens is that you end up with a loss of bifidobacteria. either because you killed it. So I killed my bifidobacteria during the pandemic.
And what I noticed was a, what I call a bifidobacteria bacteroides gap, essentially. And I feel that the virus penetrates when that gap, you know, what we call leaky gut is not really defined. And it's really because the microbiome kind of opens up. You've got a loss of bifidobacteria. You've got high bacteroides, which we've come to realize is linked with anxiety.
So, you know, when you see that and you see the signature microbiome, and of course, there's other microbes that are disappearing. the virus penetrates. And I'm going to be showing that in my own case where I've seen viruses come in and viruses go and being symptomatic, not being symptomatic and what it all does. So that's coming in the future as a case.
Well, the first thing is when I stepped into the microbiome, I realized, wow, there's so many discrepancies, right? So many labs out there, so much non-validation, so much non-reproducibility, right? So the first thing I did was analyze my stools with different labs and I got different results. even the same stool sample, different results.
So I said, well, how can I understand the microbiome before and after fecal transplant when I improve a disease if I can't even have the same lab validated, verified, and reproducible? And so I created Progena Biome really with that interest. I told my genetic sequencing, my scientist was behind the BRCA gene. And I said to him, I said, I want an assay that is valid, verified, and reproducible.
So if I test myself today, tomorrow, and I don't change anything, it's still Sabine Hazen. I'm going to be able to recognize my signature microbiome. So that was the first thing, was developing that assay. Once we developed that assay, It became complex because we started realizing, wait a minute, there's no normals. Everybody's different. So how do you compare? How do I compare me to you?
For example, you just came back from New York. I just came back from Austin. I ate Mexican food. You ate like whatever. And so, you know... Our microbiomes are probably very different and yet we feel like we're normal, right? So how is there a normal? How do you capture that microbiome that you're not really looking at the food that you ate last night, right? So that was another challenge.
The third challenge was how do you capture all that data in a bioinformatics pipeline? Because even the bioinformatics pipeline were flawed. And, you know, you would send the result, the sequences to one pipeline and you would get, again, different results. So it really is, you know, a methodical analysis of the microbiome. It's really precise.
It's really, you have to normalize these samples up to a certain level and you have to really do the clinical, right? So in other words- Well, what did I eat? What did I take? Did I take antibiotics? Was I on medications? And then you compare it to families and then you say, okay, well, let me see what the family looks like.
Oh, the family seems to have these microbes and your kid is lacking these microbes that you all have in the family. What happened? Why is the kid autistic and lacking these microbes, for example, right? So that was really, you know, the whole...
point of progena biome was really to validate to use my experience having done clinical trials for pharmaceutical companies to now bring pharmaceutical companies to say listen you guys have been you know putting one product after another but we're never reaching a cure can we be a little bit more precise can we see what these drugs are doing can we see what you know the vaccine's doing?
Can we see what antibiotics are doing? Can we see maybe one antibiotic improves bifidobacteria, maybe another doesn't? What does Tamiflu do? What does Repdesivir do to the microbiome? So this is basically the path that I want to get us into to develop these markers and to say, look, this is what autoimmune
process looks like this is what leaky gut looks like right so if you look at the data and to get back to your question on leaky gut it's exactly we don't you wouldn't know from the literature because unfortunately 90 percent of the literature out there and i read it all day long it's flawed i can't reproduce it if i can't reproduce it It's not valid.
So if somebody writes a paper on, well, this microbe is Parkinson's, and I'm looking at my 50 patients that I've analyzed that have Parkinson's, and I don't find this microbe, we have a problem. Yes.
Well, the first thing I would say is calm down, de-stress. We don't have all the data right now. There's hope in the horizon. However... Beware, and you know, Scott Jackson at the National Institute of Standard, who's gonna be hopefully working with me in the future, you know, says a beautiful sentence, which is customer beware.
And I think the customer needs to beware that these stool samples that they're doing out there are just not there yet. And here's the other problem. When you see Bacteroides vulgaris, what does that mean? Don't panic and think you need to kill things. You know, I see so many things on social media and influencers that are saying, Kill the parasites, kill the parasites. I'm a gastroenterologist.
I look for parasites all day long. If I don't see a parasite, I'm not going to give a patient a cleanse. Because here's the thing, the cleanse will kill the parasite that you may have, but it will kill your microbiome as well. And good luck bringing back your microbiome when you don't even know what it looks like or what it looked like, right? Because it's like a broken glass.
That you have no idea what it looked like. You're trying to rebuild it. So beware. And, you know, there is research. We're coming out with a lot of exciting things, a lot of exciting therapeutics in the microbiome space with autism, Alzheimer's, Parkinson's, hopefully. But in the meantime, calm down. Make sure you're taking good vitamins. You're going into the sun. You're hiking.
You're eating real food. You're... Making sure you know where your food's coming from, your farm, your beef. I like regenerative beef myself, et cetera. If you're vegan and vegan does great for your gut, stick to it. If you're vegetarian and vegetarian is great for your gut, stick to it. If you're carnivore, stick to it.
I think the thing that we're noticing about the microbiome is we're all different. And we all have different diet needs. I was born in Morocco, but I have Greek ancestry, Italian. So my diet is more Italian, Mediterranean food. The person that's from China probably needs to look back at where his ancestors were.
Showing 21–40 of 74 · page 2 of 4
← Previous
Next →