Dr. Sabine Hazan

Yeah, so I'm coming out with a case report and that's really my case report during the pandemic because I was the guinea pig. And so I kind of followed myself through the pandemic. And what I think happens is that you end up with a loss of bifidobacteria. either because you killed it. So I killed my bifidobacteria during the pandemic.

Yeah, so I'm coming out with a case report and that's really my case report during the pandemic because I was the guinea pig. And so I kind of followed myself through the pandemic. And what I think happens is that you end up with a loss of bifidobacteria. either because you killed it. So I killed my bifidobacteria during the pandemic.

And what I noticed was a, what I call a bifidobacteria bacteroides gap, essentially. And I feel that the virus penetrates when that gap, you know, what we call leaky gut is not really defined. And it's really because the microbiome kind of opens up. You've got a loss of bifidobacteria. You've got high bacteroides, which we've come to realize is linked with anxiety.

And what I noticed was a, what I call a bifidobacteria bacteroides gap, essentially. And I feel that the virus penetrates when that gap, you know, what we call leaky gut is not really defined. And it's really because the microbiome kind of opens up. You've got a loss of bifidobacteria. You've got high bacteroides, which we've come to realize is linked with anxiety.

So, you know, when you see that and you see the signature microbiome, and of course, there's other microbes that are disappearing. the virus penetrates. And I'm going to be showing that in my own case where I've seen viruses come in and viruses go and being symptomatic, not being symptomatic and what it all does. So that's coming in the future as a case.

So, you know, when you see that and you see the signature microbiome, and of course, there's other microbes that are disappearing. the virus penetrates. And I'm going to be showing that in my own case where I've seen viruses come in and viruses go and being symptomatic, not being symptomatic and what it all does. So that's coming in the future as a case.

Well, the first thing is when I stepped into the microbiome, I realized, wow, there's so many discrepancies, right? So many labs out there, so much non-validation, so much non-reproducibility, right? So the first thing I did was analyze my stools with different labs and I got different results. even the same stool sample, different results.

Well, the first thing is when I stepped into the microbiome, I realized, wow, there's so many discrepancies, right? So many labs out there, so much non-validation, so much non-reproducibility, right? So the first thing I did was analyze my stools with different labs and I got different results. even the same stool sample, different results.

So I said, well, how can I understand the microbiome before and after fecal transplant when I improve a disease if I can't even have the same lab validated, verified, and reproducible? And so I created Progena Biome really with that interest. I told my genetic sequencing, my scientist was behind the BRCA gene. And I said to him, I said, I want an assay that is valid, verified, and reproducible.

So I said, well, how can I understand the microbiome before and after fecal transplant when I improve a disease if I can't even have the same lab validated, verified, and reproducible? And so I created Progena Biome really with that interest. I told my genetic sequencing, my scientist was behind the BRCA gene. And I said to him, I said, I want an assay that is valid, verified, and reproducible.

So if I test myself today, tomorrow, and I don't change anything, it's still Sabine Hazen. I'm going to be able to recognize my signature microbiome. So that was the first thing, was developing that assay. Once we developed that assay, It became complex because we started realizing, wait a minute, there's no normals. Everybody's different. So how do you compare? How do I compare me to you?

So if I test myself today, tomorrow, and I don't change anything, it's still Sabine Hazen. I'm going to be able to recognize my signature microbiome. So that was the first thing, was developing that assay. Once we developed that assay, It became complex because we started realizing, wait a minute, there's no normals. Everybody's different. So how do you compare? How do I compare me to you?

For example, you just came back from New York. I just came back from Austin. I ate Mexican food. You ate like whatever. And so, you know... Our microbiomes are probably very different and yet we feel like we're normal, right? So how is there a normal? How do you capture that microbiome that you're not really looking at the food that you ate last night, right? So that was another challenge.

For example, you just came back from New York. I just came back from Austin. I ate Mexican food. You ate like whatever. And so, you know... Our microbiomes are probably very different and yet we feel like we're normal, right? So how is there a normal? How do you capture that microbiome that you're not really looking at the food that you ate last night, right? So that was another challenge.

The third challenge was how do you capture all that data in a bioinformatics pipeline? Because even the bioinformatics pipeline were flawed. And, you know, you would send the result, the sequences to one pipeline and you would get, again, different results. So it really is, you know, a methodical analysis of the microbiome. It's really precise.

The third challenge was how do you capture all that data in a bioinformatics pipeline? Because even the bioinformatics pipeline were flawed. And, you know, you would send the result, the sequences to one pipeline and you would get, again, different results. So it really is, you know, a methodical analysis of the microbiome. It's really precise.

It's really, you have to normalize these samples up to a certain level and you have to really do the clinical, right? So in other words- Well, what did I eat? What did I take? Did I take antibiotics? Was I on medications? And then you compare it to families and then you say, okay, well, let me see what the family looks like.

It's really, you have to normalize these samples up to a certain level and you have to really do the clinical, right? So in other words- Well, what did I eat? What did I take? Did I take antibiotics? Was I on medications? And then you compare it to families and then you say, okay, well, let me see what the family looks like.

Oh, the family seems to have these microbes and your kid is lacking these microbes that you all have in the family. What happened? Why is the kid autistic and lacking these microbes, for example, right? So that was really, you know, the whole...

Oh, the family seems to have these microbes and your kid is lacking these microbes that you all have in the family. What happened? Why is the kid autistic and lacking these microbes, for example, right? So that was really, you know, the whole...