Dr. Sarah Berry

You know, 50% of the population at some point are going to go through the menopause. And it's a transitional period of great disturbance, great disruption and of great burden to many women. And we've conducted lots of research at Zoe on the menopause.

You know, 50% of the population at some point are going to go through the menopause. And it's a transitional period of great disturbance, great disruption and of great burden to many women. And we've conducted lots of research at Zoe on the menopause.

And what we know is that prior to the menopause, which is basically the point one year after your last menstrual cycle, you have this perimenopausal transition period. where your oestrogen and other hormones are fluctuating day to day. So it's like this roller coaster, which I think your graph shows really nicely. You've got this roller coaster of hormones.

And what we know is that prior to the menopause, which is basically the point one year after your last menstrual cycle, you have this perimenopausal transition period. where your oestrogen and other hormones are fluctuating day to day. So it's like this roller coaster, which I think your graph shows really nicely. You've got this roller coaster of hormones.

And so what's happening is your oestrogen isn't just slowly declining as you reach perimenopause, so that transitional period before your menopause, but you're on this roller coaster. And it becomes more regulated after the menopause. But you're still in that point where you're having less oestrogen, so less of the hormone that we know has such wide-reaching effects.

And so what's happening is your oestrogen isn't just slowly declining as you reach perimenopause, so that transitional period before your menopause, but you're on this roller coaster. And it becomes more regulated after the menopause. But you're still in that point where you're having less oestrogen, so less of the hormone that we know has such wide-reaching effects.

And the reason that the perimenopause transition as well as postmenopause period in a woman's life is so important is because oestrogen, the hormone that fluctuates during the perimenopause and then reduces and declines in postmenopause, It has effects all over our body. Nearly every cell in our body has oestrogen receptors. So our brain, our blood vessels, nearly everywhere.

And the reason that the perimenopause transition as well as postmenopause period in a woman's life is so important is because oestrogen, the hormone that fluctuates during the perimenopause and then reduces and declines in postmenopause, It has effects all over our body. Nearly every cell in our body has oestrogen receptors. So our brain, our blood vessels, nearly everywhere.

So this roller coaster of oestrogen during the perimenopausal phase and also the reduction postmenopausally has far reaching effects.

So this roller coaster of oestrogen during the perimenopausal phase and also the reduction postmenopausally has far reaching effects.

health effects so for example postmenopausally women are five times greater risk of having a heart attack now some of that's due to age but it's also due to the loss in oestrogen women are five times more likely to have abdominal obesity which is fat around the tummy and that's because of oestrogen's role in fat tissue deposition so where fat tissue is deposited

health effects so for example postmenopausally women are five times greater risk of having a heart attack now some of that's due to age but it's also due to the loss in oestrogen women are five times more likely to have abdominal obesity which is fat around the tummy and that's because of oestrogen's role in fat tissue deposition so where fat tissue is deposited

We see in our own ZOE predict research, premenopause, women are doing well compared to men in terms of many of these, what we call intermediary risk factors of cardiovascular disease, blood pressure, cholesterol, glucose, insulin, et cetera. As soon as they hit the menopause, suddenly they catch up with men. And it gets worse.

We see in our own ZOE predict research, premenopause, women are doing well compared to men in terms of many of these, what we call intermediary risk factors of cardiovascular disease, blood pressure, cholesterol, glucose, insulin, et cetera. As soon as they hit the menopause, suddenly they catch up with men. And it gets worse.

And so suddenly their blood pressure is higher than men or their cholesterol is the same level as men. So we see this as well in our ZOE predict research that postmenopausally and perimenopausally people's cholesterol and their bad cholesterol, their LDL cholesterol increases by 25%. And this is all related to the wide reaching role that oestrogen has. in our body.

And so suddenly their blood pressure is higher than men or their cholesterol is the same level as men. So we see this as well in our ZOE predict research that postmenopausally and perimenopausally people's cholesterol and their bad cholesterol, their LDL cholesterol increases by 25%. And this is all related to the wide reaching role that oestrogen has. in our body.

We also see the oestrogen impacts and therefore the perimenopause and postmenopause, how we metabolize food. So we see bigger excursions in post-meal glucose and post-meal fat after the menopause. Again, it's all linked to the role that oestrogen plays in our metabolism. And then I think what's most important

We also see the oestrogen impacts and therefore the perimenopause and postmenopause, how we metabolize food. So we see bigger excursions in post-meal glucose and post-meal fat after the menopause. Again, it's all linked to the role that oestrogen plays in our metabolism. And then I think what's most important

To be aware of regarding the perimenopause and postmenopause phase is the symptoms that women experience. And we've done some research in 70,000 individuals where we've looked at how prevalent these symptoms are. we see that 99% of perimenopausal women experience at least one menopausal symptom. We see that 66% of perimenopausal women have 12 symptoms or more. And this has a huge burden.

To be aware of regarding the perimenopause and postmenopause phase is the symptoms that women experience. And we've done some research in 70,000 individuals where we've looked at how prevalent these symptoms are. we see that 99% of perimenopausal women experience at least one menopausal symptom. We see that 66% of perimenopausal women have 12 symptoms or more. And this has a huge burden.