Dr. Sarah Berry
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There's also a consent box to tick when they do it to say that if they're happy to, they can share the data back with scientists, i.e. me and my team. So there's a kind of double benefit that they also become a community scientist because they share their data back with us, which enables us
I'd like to caveat with I'm not an expert in lean muscle mass area. I'm very quick to point out what I'm not an expert in rather than what I am an expert in. From what we have researched and what I know, I would totally agree with you that it's such an important age as you enter perimenopause and postmenopause. It's such an important age to maintain muscle mass.
I'd like to caveat with I'm not an expert in lean muscle mass area. I'm very quick to point out what I'm not an expert in rather than what I am an expert in. From what we have researched and what I know, I would totally agree with you that it's such an important age as you enter perimenopause and postmenopause. It's such an important age to maintain muscle mass.
I'd like to caveat with I'm not an expert in lean muscle mass area. I'm very quick to point out what I'm not an expert in rather than what I am an expert in. From what we have researched and what I know, I would totally agree with you that it's such an important age as you enter perimenopause and postmenopause. It's such an important age to maintain muscle mass.
It's such an important age to be doing weight-bearing exercises to maintain bone mineral density because we know that also reduces during the menopause. And maintaining muscle mass is important, in my opinion, for peri- and post-menopausal women for a number of reasons, some of those that you've mentioned. but also to maintain insulin sensitivity.
It's such an important age to be doing weight-bearing exercises to maintain bone mineral density because we know that also reduces during the menopause. And maintaining muscle mass is important, in my opinion, for peri- and post-menopausal women for a number of reasons, some of those that you've mentioned. but also to maintain insulin sensitivity.
It's such an important age to be doing weight-bearing exercises to maintain bone mineral density because we know that also reduces during the menopause. And maintaining muscle mass is important, in my opinion, for peri- and post-menopausal women for a number of reasons, some of those that you've mentioned. but also to maintain insulin sensitivity.
And what we've seen very clearly with a paper that we published back in 2022, that people's insulin sensitivity, if you're peri or postmenopausal, is different if you're premenopausal. And so the more you can maintain your muscle mass, the more insulin sensitive you might be able to maintain. And we looked at people's post-meal sugar responses.
And what we've seen very clearly with a paper that we published back in 2022, that people's insulin sensitivity, if you're peri or postmenopausal, is different if you're premenopausal. And so the more you can maintain your muscle mass, the more insulin sensitive you might be able to maintain. And we looked at people's post-meal sugar responses.
And what we've seen very clearly with a paper that we published back in 2022, that people's insulin sensitivity, if you're peri or postmenopausal, is different if you're premenopausal. And so the more you can maintain your muscle mass, the more insulin sensitive you might be able to maintain. And we looked at people's post-meal sugar responses.
So we looked at their, what I call the postprandial glycemic response. So this is the circulating level of glucose after having a meal in that kind of two to three hours after you have a meal. And we looked at this in both pre-peri and post-menopausal women. We gave, it was about 700 individuals were given a standardized meal. that contained a really high carbohydrate load.
So we looked at their, what I call the postprandial glycemic response. So this is the circulating level of glucose after having a meal in that kind of two to three hours after you have a meal. And we looked at this in both pre-peri and post-menopausal women. We gave, it was about 700 individuals were given a standardized meal. that contained a really high carbohydrate load.
So we looked at their, what I call the postprandial glycemic response. So this is the circulating level of glucose after having a meal in that kind of two to three hours after you have a meal. And we looked at this in both pre-peri and post-menopausal women. We gave, it was about 700 individuals were given a standardized meal. that contained a really high carbohydrate load.
So it had about 80 grams of carbohydrate. And then we measured over the next four hours how their blood glucose changed in response to that meal. And what we found is the peri and the postmenopausal women had a lot higher blood glucose response to that standardized meal compared to the premenopausal women. Now, we do expect insulin sensitivity and muscle mass to change anyway as part of aging.
So it had about 80 grams of carbohydrate. And then we measured over the next four hours how their blood glucose changed in response to that meal. And what we found is the peri and the postmenopausal women had a lot higher blood glucose response to that standardized meal compared to the premenopausal women. Now, we do expect insulin sensitivity and muscle mass to change anyway as part of aging.
So it had about 80 grams of carbohydrate. And then we measured over the next four hours how their blood glucose changed in response to that meal. And what we found is the peri and the postmenopausal women had a lot higher blood glucose response to that standardized meal compared to the premenopausal women. Now, we do expect insulin sensitivity and muscle mass to change anyway as part of aging.
And because we know that menopause is an age-related event, what we wanted to do is think, okay, is there a way that we can see, is this due to age or is it due to oestrogen? Is it due to the menopause? So because we had quite a large cohort, we were able to take a subgroup of individuals and we were able to age match them.
And because we know that menopause is an age-related event, what we wanted to do is think, okay, is there a way that we can see, is this due to age or is it due to oestrogen? Is it due to the menopause? So because we had quite a large cohort, we were able to take a subgroup of individuals and we were able to age match them.
And because we know that menopause is an age-related event, what we wanted to do is think, okay, is there a way that we can see, is this due to age or is it due to oestrogen? Is it due to the menopause? So because we had quite a large cohort, we were able to take a subgroup of individuals and we were able to age match them.
So what we did is we took people who were aged the same, but half of who were peri or post and half of who were pre-menopausal.