Dr. Scott Sherr

So they actually had a smaller area where they had the stroke if you gave methylene blue very, very quickly. Again, one of the reasons why I have all of my patients with methylene blue in their medicine cabinet, just in case.

So they actually had a smaller area where they had the stroke if you gave methylene blue very, very quickly. Again, one of the reasons why I have all of my patients with methylene blue in their medicine cabinet, just in case.

In that same study, they showed that an area that wasn't affected by the stroke was mildly stressed from an energy perspective, making energy from a mitochondrial perspective. So the mitochondria were stressed in an area that was normal, but in the abnormal area had significant improvements, right? So their argument is like, well, if you have normal mitochondria, you shouldn't take methylene blue.

In that same study, they showed that an area that wasn't affected by the stroke was mildly stressed from an energy perspective, making energy from a mitochondrial perspective. So the mitochondria were stressed in an area that was normal, but in the abnormal area had significant improvements, right? So their argument is like, well, if you have normal mitochondria, you shouldn't take methylene blue.

But number one, if you have a stroke, it could be very, very potentially very, very effective, which is fantastic. But in addition, the piece that they left out is that they're using pretty high doses of methylene blue IV again in these animals, right? And so methylene blue, at least a milligram per kilogram in the IV is

But number one, if you have a stroke, it could be very, very potentially very, very effective, which is fantastic. But in addition, the piece that they left out is that they're using pretty high doses of methylene blue IV again in these animals, right? And so methylene blue, at least a milligram per kilogram in the IV is

were given to these animals showing some mitochondrial stress in an area with normal mitochondria. So this actually proves my point that higher doses of methylene blue, especially IV, should only be reserved for acute situations. If you're taking methylene blue on a regular basis, it should be oral, it should be lower dose, and it's not going to cause that mitochondrial stress.

were given to these animals showing some mitochondrial stress in an area with normal mitochondria. So this actually proves my point that higher doses of methylene blue, especially IV, should only be reserved for acute situations. If you're taking methylene blue on a regular basis, it should be oral, it should be lower dose, and it's not going to cause that mitochondrial stress.

We just haven't seen it clinically. And If I can't see it clinically, then that means that it's very likely related to their study design using higher doses of methylene blue in the IV, causing mitochondrial stress in normal areas of the tissue in the animal.

We just haven't seen it clinically. And If I can't see it clinically, then that means that it's very likely related to their study design using higher doses of methylene blue in the IV, causing mitochondrial stress in normal areas of the tissue in the animal.

So in essence, low doses of methylene blue, not IV especially, are not causing mitochondrial stress in normal mitochondria in people that are well-optimized, as well as all the other reasons why it's important to make these distinctions between all these different types of populations.

So in essence, low doses of methylene blue, not IV especially, are not causing mitochondrial stress in normal mitochondria in people that are well-optimized, as well as all the other reasons why it's important to make these distinctions between all these different types of populations.

You just actually hit another point where I just realized as well, right? So we are not supposed to live until after about 40 years of age, right? Right. Evolutionarily, we're supposed to be dead by then. And so most of us can pretty well have well-optimized mitochondria in our 20s and 30s because that's when we're most optimized to do almost anything, right? Right. Especially our 20s.

You just actually hit another point where I just realized as well, right? So we are not supposed to live until after about 40 years of age, right? Right. Evolutionarily, we're supposed to be dead by then. And so most of us can pretty well have well-optimized mitochondria in our 20s and 30s because that's when we're most optimized to do almost anything, right? Right. Especially our 20s.

But if you're trying to live a long life with optimized mitochondria, it's very difficult to do if you're not supporting them in other ways. Yes. After we get about over the age of 40 or so, for sure. So that's the other piece that I never really thought about until you just said it is that aging will deteriorate your mitochondria no matter what. Right. And so we need the support, right?

But if you're trying to live a long life with optimized mitochondria, it's very difficult to do if you're not supporting them in other ways. Yes. After we get about over the age of 40 or so, for sure. So that's the other piece that I never really thought about until you just said it is that aging will deteriorate your mitochondria no matter what. Right. And so we need the support, right?

What you say is like the mitochondria is sort of like your common denominator for almost all signs of aging and deterioration. Your mitochondria, they're making a lot of energy, so they make a lot of rust over time. They rust the system. And that's one of the things that ages the system over time too, the oxidative stress. related to making energy. And that affects the mitochondria itself.

What you say is like the mitochondria is sort of like your common denominator for almost all signs of aging and deterioration. Your mitochondria, they're making a lot of energy, so they make a lot of rust over time. They rust the system. And that's one of the things that ages the system over time too, the oxidative stress. related to making energy. And that affects the mitochondria itself.

It affects the cell membranes. It affects other areas, the DNA, of course, too.

It affects the cell membranes. It affects other areas, the DNA, of course, too.