Dr. Scott Sherr

And getting more GABA involved can be very effective here. And this is why a lot of the drugs that are involved in treating epilepsy are working on the GABA receptors themselves things like gabapentin for example which is a drug that works on the GABA receptors in a pretty novel way and actually we don't really understand exactly how that drug particularly works but that's an example of that

And getting more GABA involved can be very effective here. And this is why a lot of the drugs that are involved in treating epilepsy are working on the GABA receptors themselves things like gabapentin for example which is a drug that works on the GABA receptors in a pretty novel way and actually we don't really understand exactly how that drug particularly works but that's an example of that

There's also some degeneration in Parkinson's and in Huntington's as well that you were describing that's also affecting the glutamate and the GABA balance. And that's why you get choreic movements with Huntington's, which is like these movements that Huntington's patients will make are because of a imbalance between your glutamate and your GABA levels.

There's also some degeneration in Parkinson's and in Huntington's as well that you were describing that's also affecting the glutamate and the GABA balance. And that's why you get choreic movements with Huntington's, which is like these movements that Huntington's patients will make are because of a imbalance between your glutamate and your GABA levels.

There's also some degeneration in Parkinson's and in Huntington's as well that you were describing that's also affecting the glutamate and the GABA balance. And that's why you get choreic movements with Huntington's, which is like these movements that Huntington's patients will make are because of a imbalance between your glutamate and your GABA levels.

And so this is what's happening in Parkinson's we think as well. There's also some studies that show that there's a dysregulation of the GABA neurons as well in schizophrenia at the same time. If you have an imbalance between your glutamate and your GABA systems, you're going to have excitability of the brain that is hard to control.

And so this is what's happening in Parkinson's we think as well. There's also some studies that show that there's a dysregulation of the GABA neurons as well in schizophrenia at the same time. If you have an imbalance between your glutamate and your GABA systems, you're going to have excitability of the brain that is hard to control.

And so this is what's happening in Parkinson's we think as well. There's also some studies that show that there's a dysregulation of the GABA neurons as well in schizophrenia at the same time. If you have an imbalance between your glutamate and your GABA systems, you're going to have excitability of the brain that is hard to control.

It can be disease pathology like Parkinson's, Huntington's, schizophrenia, but it can also be in mental health time kinds of conditions as we were describing. depression, anxiety, insomnia, irritability, tremors as well. So all these can be a part of agglutamate overabundance versus GABA deficiency. And it's that GABA deficiency that we really need to focus on more.

It can be disease pathology like Parkinson's, Huntington's, schizophrenia, but it can also be in mental health time kinds of conditions as we were describing. depression, anxiety, insomnia, irritability, tremors as well. So all these can be a part of agglutamate overabundance versus GABA deficiency. And it's that GABA deficiency that we really need to focus on more.

It can be disease pathology like Parkinson's, Huntington's, schizophrenia, but it can also be in mental health time kinds of conditions as we were describing. depression, anxiety, insomnia, irritability, tremors as well. So all these can be a part of agglutamate overabundance versus GABA deficiency. And it's that GABA deficiency that we really need to focus on more.

Yes, of course. And so those are the two main types of GABA receptors. GABA-A is the more common one. GABA-B is also very common. So GABA-A receptors have what are called these subunits. They have five subunits on them that change depending on where they are in the brain. GABA-A receptors are everywhere in the brain, but some are more focused on anxiety relief. Some are more focused on sleep.

Yes, of course. And so those are the two main types of GABA receptors. GABA-A is the more common one. GABA-B is also very common. So GABA-A receptors have what are called these subunits. They have five subunits on them that change depending on where they are in the brain. GABA-A receptors are everywhere in the brain, but some are more focused on anxiety relief. Some are more focused on sleep.

Yes, of course. And so those are the two main types of GABA receptors. GABA-A is the more common one. GABA-B is also very common. So GABA-A receptors have what are called these subunits. They have five subunits on them that change depending on where they are in the brain. GABA-A receptors are everywhere in the brain, but some are more focused on anxiety relief. Some are more focused on sleep.

Some are more focused on sensorial gating, like in the thalamic area, for example. The thalamus has lots of GABA-A receptors. And so the GABA-A receptor, the way it works is that it has a central channel called a chloride channel. And what happens is when GABA binds to the receptor, this channel opens. When this channel opens, chloride channels go, the chloride goes in.

Some are more focused on sensorial gating, like in the thalamic area, for example. The thalamus has lots of GABA-A receptors. And so the GABA-A receptor, the way it works is that it has a central channel called a chloride channel. And what happens is when GABA binds to the receptor, this channel opens. When this channel opens, chloride channels go, the chloride goes in.

Some are more focused on sensorial gating, like in the thalamic area, for example. The thalamus has lots of GABA-A receptors. And so the GABA-A receptor, the way it works is that it has a central channel called a chloride channel. And what happens is when GABA binds to the receptor, this channel opens. When this channel opens, chloride channels go, the chloride goes in.

Sorry, the chloride goes out, excuse me. Chloride goes out. And when the chloride goes out, what happens is that the GABA receptor and the GABA receptor itself, which is on a neuron, remember, is going to what's called hyperpolarize, which means that it stops firing. So that's what happens here. So I misspoke. So chloride's going in, not out. Okay, so chloride's going into the channel.

Sorry, the chloride goes out, excuse me. Chloride goes out. And when the chloride goes out, what happens is that the GABA receptor and the GABA receptor itself, which is on a neuron, remember, is going to what's called hyperpolarize, which means that it stops firing. So that's what happens here. So I misspoke. So chloride's going in, not out. Okay, so chloride's going into the channel.

Sorry, the chloride goes out, excuse me. Chloride goes out. And when the chloride goes out, what happens is that the GABA receptor and the GABA receptor itself, which is on a neuron, remember, is going to what's called hyperpolarize, which means that it stops firing. So that's what happens here. So I misspoke. So chloride's going in, not out. Okay, so chloride's going into the channel.