Dr. Tony Wyss-Coray

But have it tailored to your specific needs.

And then we can test, does that intervention actually change the age of your organ?

Absolutely.

So in many diseases, complex diseases, Alzheimer's disease in particular, we know that people have probably different forms of Alzheimer's disease.

And we know there are risk factors that predispose you to have Alzheimer's disease.

But most of the trials now are done in all comers with the disease who already have the diagnosis.

And so you could imagine that if you have these predictors of change, the predictors of risk, and you get actually more resolution, and we can talk about that in a minute, what the next stages of this type of research, you may get different profiles in people and say, okay, let's test this new drug in this type of Alzheimer's disease who has a very particular risk profile.

rather than in everyone and then the drug fails.

I think we may have tested a lot of drugs out there that might actually be beneficial, but because we apply them to everyone and we apply them too late, they fail and we throw them away.

Yeah, I mean, this is not my area of expertise, but just as a blank statement, there is no human intervention that can extend lifespan that has been tested or validated.

There are many that have shown beneficial effects in animal models, including NMN and all these metabolites.

there's actually a clinical study that shows that if you take these supplements, they increase your levels in the blood.

That's a good clinical study, but it doesn't show that it has an effect on lifespan or even on frailty or any other tangible outcome.

And this is the case with many other medications that might be beneficial, but they have simply not been tested in a clinical trial.

They have been tested in disease sometimes, and they are...

very good drugs to treat a person who is sick, but they have not been tested in healthy, elder people and see whether they reduce aging or increase health span.

There's really nothing out there except

exercise and diets.

Those have sort of proven effects.

There's a very good study from a researcher in Singapore who tested 10 different preparations of NMN and she found that many of them actually don't contain