Dr. Tony Wyss-Coray

So there were similar factors in humans as in mice.

And then we went a step further and worked, collaborated very closely with a company called Griffles, who is producing mice.

clinical medicines for hospitals based on plasma donation.

So they have centers where volunteers donate plasma and then they pool this and they isolate

For example, antibodies.

So if you're immunodeficient or you have cancer therapy and you are immunosuppressed, you will get regular infusions of antibodies that are sourced from healthy people, from these volunteers.

Also, if you lose a lot of blood, you may get albumin, which is the main protein in our blood.

So this company had this manufacturing process where they collect thousands of donations and they process it into different medicines.

And this allowed us to test these different fractions and see which ones have an effect in the mice.

And again, we could find some of them that really were more powerful than others.

And so we started some clinical trials in patients with Alzheimer's disease and Parkinson's disease and infused them with these fractions that we've shown have effects in mice.

These were small trials, but they looked promising.

And they're related to what people have been observing previously, that if you get a blood transfusions, often people have sort of feel invigorated or their mind, they say their mind got cleared or they improved.

And this company actually, Griffles, had also run a clinical study that was

blinded, placebo-controlled, in patients with Alzheimer's disease where they first removed their plasma.

This is called therapeutic plasma exchange.

And then infused them back with a major blood component, this albumin, which also contains other factors.

And they saw clear significant benefits.

And this was in 500 patients.

So the field is trying to figure out next steps and hopefully do...