Dr. Trisha Pasricha

speaker

2,195 appearances 5 recordings 5 series first heard Mar 2026 last heard 8 Jul

Dr. Trisha Pasricha’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 5 in all, peaking in Apr 2026 with 2.

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Science Friday · How does the gut-brain connection work? · 8 Jul 2026 podcast

It extends down from the brain to almost every internal organ, but it has a very close relationship with the gut.

Now, the gut, to communicate back up to the brain, it can't

quite use the bloodstream the same way because the brain has enacted this like really rugged barrier called the blood brain barrier.

And so it doesn't let a lot of things cross through, although some does.

Most of how the gut communicates with the brain is through the vagus nerve.

And the cool thing that we've learned is just how much of that communication in the vagus nerve is not top down.

Most of it, 80% of it is from the gut upwards.

So the gut is doing talking all the time.

We don't perceive

consciously most of that communication.

Our conscious brains perceive what comes to us from our five senses, our eyesight, what we hear, what we feel, what we smell.

But there's this whole realm called interoception, which is

all the information from inside your body that is reaching your brain at the same time every second your brain has to grapple with that while also dealing with that outside information that internal set of signals is called interoception and your gut all of it that communication for the most part is happening without you consciously realizing it and i think that's why it's been neglected for so long but it's been happening under the radar nonetheless

Yeah.

You know, we have had hints that there may be more to Parkinson's than just the brain for a long time.

If you go back to James Parkinson's early writing and his first case description of these patients, he did notice that they tended to have just incredibly severe constipation.

I wasn't sure why.

And when I started my GI fellowship, by chance, I started seeing a lot of patients with Parkinson's disease, people with Parkinson's disease.

And they would just tell me, I have had constipation.

It started 10 years, 20 years before these motor symptoms.

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