Dr. Will Bulsiewicz

We want it to be in the sweet spot.

And what this study in 2021 showed us, Jonathan, was the way in which specifically our blood fat levels after a meal are associated with inflammation.

What I'm saying is that

Zoe research has shown us that there is inflammation that occurs after a meal, and that it is worse if your triglycerides are spiking out of control, that it will stay elevated for six to eight hours, and that your gut microbiome plays a really, really important role in explaining where that is coming from.

Some of the things that I discuss in the new book are the, the levers that we can pull, which are actionable opportunities that

to repair and restore the gut microbiome.

And in doing so, strengthen and fortify the gut barrier and create a healthy immune system.

And so some of the research that we've done during the last five, six years together at Zoe has contributed to that because for example,

One of the chapters in my book is entirely about circadian rhythm.

And we conducted the world's largest fasting study.

I'm incredibly proud of the fact that we at Zoe managed to get close to 40,000 people participating in a research study where they're adding time-restricted eating into their daily habit, into their daily lifestyle.

And those people felt significant benefits, more energy, less bloating.

Their mood was improved.

And in a fascinating twist, their hunger was less.

Each of these things fits so nicely as a piece of the puzzle into this conversation that we're having.

around inflammation, that that explains like that is the real world manifestation of what we are learning about the power of the circadian rhythm.

That if you do simple things like address the regularity of your mealtimes,

and maintain consistent eating windows, you can achieve these types of effects, energy, mood, hunger, bloating, all improved.

Well, we can't say that from the ZOE trial itself, because unfortunately, this was a remote study.

You can't get to 40,000 people and simultaneously get detailed elements like blood work.