Dr. Will Bulsiewicz

Well, if I scrape my knee or if my son scrapes his knee and I want to clean up that wound, what do I pull out?

Exactly. Because it's inherently antimicrobial, right? And so what do we think happens when we ingest? And why do we get hangovers? Is the hangover just dehydration? Because I can drink a lot of Gatorade the morning after I've gone too far and I'm still going to feel that hangover for about 24 hours.

Exactly. Because it's inherently antimicrobial, right? And so what do we think happens when we ingest? And why do we get hangovers? Is the hangover just dehydration? Because I can drink a lot of Gatorade the morning after I've gone too far and I'm still going to feel that hangover for about 24 hours.

Exactly. Because it's inherently antimicrobial, right? And so what do we think happens when we ingest? And why do we get hangovers? Is the hangover just dehydration? Because I can drink a lot of Gatorade the morning after I've gone too far and I'm still going to feel that hangover for about 24 hours.

I think that a hangover is that we've actually induced dysbiosis through excessive alcohol consumption. And there was a study that changed my mind about alcohol. I used to think that one or two drinks was okay. Like as long as you don't have a hangover, you're okay. And I've changed my mind on that. I actually think... Let me start by saying this. I'm not a teetotaler.

I think that a hangover is that we've actually induced dysbiosis through excessive alcohol consumption. And there was a study that changed my mind about alcohol. I used to think that one or two drinks was okay. Like as long as you don't have a hangover, you're okay. And I've changed my mind on that. I actually think... Let me start by saying this. I'm not a teetotaler.

I think that a hangover is that we've actually induced dysbiosis through excessive alcohol consumption. And there was a study that changed my mind about alcohol. I used to think that one or two drinks was okay. Like as long as you don't have a hangover, you're okay. And I've changed my mind on that. I actually think... Let me start by saying this. I'm not a teetotaler.

So like there will be someone who hears this and then you might see me out socially with friends and I'm having a drink, right? That's okay. Like we're not trying to be perfect here. But the point from my perspective is that the evidence is indicating to me that the best place for us to be is to not have regular alcohol. This was the study.

So like there will be someone who hears this and then you might see me out socially with friends and I'm having a drink, right? That's okay. Like we're not trying to be perfect here. But the point from my perspective is that the evidence is indicating to me that the best place for us to be is to not have regular alcohol. This was the study.

So like there will be someone who hears this and then you might see me out socially with friends and I'm having a drink, right? That's okay. Like we're not trying to be perfect here. But the point from my perspective is that the evidence is indicating to me that the best place for us to be is to not have regular alcohol. This was the study.

They took a group of people and they had them consume a significant amount of alcohol relative to their body weight. And then they measured every 30 minutes their blood alcohol level and the presence of lipopolysaccharide in their blood, in their bloodstream. All right. I mentioned this lipopolysaccharide a while back in the episode. So let me explain what that is.

They took a group of people and they had them consume a significant amount of alcohol relative to their body weight. And then they measured every 30 minutes their blood alcohol level and the presence of lipopolysaccharide in their blood, in their bloodstream. All right. I mentioned this lipopolysaccharide a while back in the episode. So let me explain what that is.

They took a group of people and they had them consume a significant amount of alcohol relative to their body weight. And then they measured every 30 minutes their blood alcohol level and the presence of lipopolysaccharide in their blood, in their bloodstream. All right. I mentioned this lipopolysaccharide a while back in the episode. So let me explain what that is.

In our gut is a mix of different types of microbes. And many of them are really good for us. Most of them are good for us. But some of them are bad. E. coli is definitely in our gut. Every single one of us has that in there. And these inflammatory pathogenic bacteria, they have this coat of armor that surrounds the cell and protects them called lipopolysaccharide. And it's specific to pathogens.

In our gut is a mix of different types of microbes. And many of them are really good for us. Most of them are good for us. But some of them are bad. E. coli is definitely in our gut. Every single one of us has that in there. And these inflammatory pathogenic bacteria, they have this coat of armor that surrounds the cell and protects them called lipopolysaccharide. And it's specific to pathogens.

In our gut is a mix of different types of microbes. And many of them are really good for us. Most of them are good for us. But some of them are bad. E. coli is definitely in our gut. Every single one of us has that in there. And these inflammatory pathogenic bacteria, they have this coat of armor that surrounds the cell and protects them called lipopolysaccharide. And it's specific to pathogens.

So our immune system was trained to be activated in response to this. It's supposed to stay in our gut. That's why we have a gut barrier. But if the gut barrier gets broken down for whatever reason, then that E. coli or that lipopolysaccharide that's in our gut can sneak across the gut barrier and get into the bloodstream and come into contact with the immune system, which results in inflammation.

So our immune system was trained to be activated in response to this. It's supposed to stay in our gut. That's why we have a gut barrier. But if the gut barrier gets broken down for whatever reason, then that E. coli or that lipopolysaccharide that's in our gut can sneak across the gut barrier and get into the bloodstream and come into contact with the immune system, which results in inflammation.

So our immune system was trained to be activated in response to this. It's supposed to stay in our gut. That's why we have a gut barrier. But if the gut barrier gets broken down for whatever reason, then that E. coli or that lipopolysaccharide that's in our gut can sneak across the gut barrier and get into the bloodstream and come into contact with the immune system, which results in inflammation.

So this is like, to me, lipopolysaccharide is synonymous with inflammation. So they were checking lipopolysaccharide levels in the blood. Again, we should not be seeing much lipopolysaccharide there when our gut barrier is working.