Dr. Will Cole

And then every few years, we hear about more and more autoimmune components to this and to that and to this. The things that we weren't even classified a decade ago as autoimmune, now we're finding autoimmune components. So if you break that word down, auto, that prefix, self-immune, it's when the immune system turns against itself at that event that they sort of

seminal event within autoimmunity called molecular mimicry. The case of mistaken identity when the immune system is tagging antibodies, flags for destruction, to destroy. So against the thyroid, it's against thyroproxidase, the enzyme that makes the thyroid, or thyroglobulin, which is the thyroid protein itself. But then you can think about ulcerative colitis, it's in the gut.

seminal event within autoimmunity called molecular mimicry. The case of mistaken identity when the immune system is tagging antibodies, flags for destruction, to destroy. So against the thyroid, it's against thyroproxidase, the enzyme that makes the thyroid, or thyroglobulin, which is the thyroid protein itself. But then you can think about ulcerative colitis, it's in the gut.

seminal event within autoimmunity called molecular mimicry. The case of mistaken identity when the immune system is tagging antibodies, flags for destruction, to destroy. So against the thyroid, it's against thyroproxidase, the enzyme that makes the thyroid, or thyroglobulin, which is the thyroid protein itself. But then you can think about ulcerative colitis, it's in the gut.

Crohn's, it's in the gut. MS, it's in the myelin sheath. Sjogren's, it's the connective tissue. Lupus, it's the connective tissue. Sjogren's, it can impact the dry eyes and the dry mouth. and rheumatoid arthritis, the joints. So we can go on and on, but that molecular mimicry is that connective mechanism within all autoimmunity.

Crohn's, it's in the gut. MS, it's in the myelin sheath. Sjogren's, it's the connective tissue. Lupus, it's the connective tissue. Sjogren's, it can impact the dry eyes and the dry mouth. and rheumatoid arthritis, the joints. So we can go on and on, but that molecular mimicry is that connective mechanism within all autoimmunity.

Crohn's, it's in the gut. MS, it's in the myelin sheath. Sjogren's, it's the connective tissue. Lupus, it's the connective tissue. Sjogren's, it can impact the dry eyes and the dry mouth. and rheumatoid arthritis, the joints. So we can go on and on, but that molecular mimicry is that connective mechanism within all autoimmunity.

And then you think of how researchers even describe molecular mimicry. It says they describe it as the immune system losing recognition of self, which you think about that on a physiological level that's happening. But then you think on a mental, emotional, spiritual level, the immune system, that person losing recognition of self. And then the research around stress and trauma.

And then you think of how researchers even describe molecular mimicry. It says they describe it as the immune system losing recognition of self, which you think about that on a physiological level that's happening. But then you think on a mental, emotional, spiritual level, the immune system, that person losing recognition of self. And then the research around stress and trauma.

And then you think of how researchers even describe molecular mimicry. It says they describe it as the immune system losing recognition of self, which you think about that on a physiological level that's happening. But then you think on a mental, emotional, spiritual level, the immune system, that person losing recognition of self. And then the research around stress and trauma.

And when we talk about Hashimoto specifically, there's a lot of stress and trauma component where these genetic variants that are associated with autoimmunity, like MTHFR is highly associated. The genetics, depending on the study that you cite, it's anywhere between 77% to 91% of the autoimmune inflammation puzzle is due to epigenetics. It's the lifestyle stuff that we're talking about here.

And when we talk about Hashimoto specifically, there's a lot of stress and trauma component where these genetic variants that are associated with autoimmunity, like MTHFR is highly associated. The genetics, depending on the study that you cite, it's anywhere between 77% to 91% of the autoimmune inflammation puzzle is due to epigenetics. It's the lifestyle stuff that we're talking about here.

And when we talk about Hashimoto specifically, there's a lot of stress and trauma component where these genetic variants that are associated with autoimmunity, like MTHFR is highly associated. The genetics, depending on the study that you cite, it's anywhere between 77% to 91% of the autoimmune inflammation puzzle is due to epigenetics. It's the lifestyle stuff that we're talking about here.

Totally agree. So genetics are part of it, like MTHFR, like HLA, like other gene variants that researchers, endocannabinoid system too. Right. But the majority of it is environmental. So that's why we're seeing this epidemic rise of Hashimoto's disease. You're right. These levels, these TPO, TGA thyroid antibodies are high in so many people.

Totally agree. So genetics are part of it, like MTHFR, like HLA, like other gene variants that researchers, endocannabinoid system too. Right. But the majority of it is environmental. So that's why we're seeing this epidemic rise of Hashimoto's disease. You're right. These levels, these TPO, TGA thyroid antibodies are high in so many people.

Totally agree. So genetics are part of it, like MTHFR, like HLA, like other gene variants that researchers, endocannabinoid system too. Right. But the majority of it is environmental. So that's why we're seeing this epidemic rise of Hashimoto's disease. You're right. These levels, these TPO, TGA thyroid antibodies are high in so many people.

Normally there's different areas, but if you look at the... When does the switch get flicked? Normally it's leaky gut syndrome. Normally when you look, and I would say most of the research is being done, is there's some sort of breach of the intestinal lining. So undigested food proteins and bacterial endotoxins called lipopolysaccharides, these bacterial toxins in gram-negative bacteria.

Normally there's different areas, but if you look at the... When does the switch get flicked? Normally it's leaky gut syndrome. Normally when you look, and I would say most of the research is being done, is there's some sort of breach of the intestinal lining. So undigested food proteins and bacterial endotoxins called lipopolysaccharides, these bacterial toxins in gram-negative bacteria.

Normally there's different areas, but if you look at the... When does the switch get flicked? Normally it's leaky gut syndrome. Normally when you look, and I would say most of the research is being done, is there's some sort of breach of the intestinal lining. So undigested food proteins and bacterial endotoxins called lipopolysaccharides, these bacterial toxins in gram-negative bacteria.

are passing through the gut lining because there's these proteins that govern gut lining permeability called occludin and zonulin. Think of the Z in zonulin, this protein that protects the gut lining, the tight junctions of the gut as a zipper. So this increased zonulin antibody activity, increased zonulin activity, You're going to have things breached, getting from the gut into the bloodstream.