Dr. William (Bill) Dodson

Second thing is that the individual response rate to any one of those medications is disappointingly low at about 30%.

So if you took 100 people and started them on whichever alpha agonist I was feeling lucky with that day, 30% of people would have a life-changing experience.

But 70%, a majority, what was that?

At that point, you stop the first one, you try the other one, and there's another different 30% of people who will get that, oh, wow, where have you been all your life?

This is what happens.

I get more benefit out of this than I do the stimulant.

Unfortunately, that's still these 40% who try most medications sequentially and unfortunately don't get much benefit.

If a person is really, really impaired,

by the rejection sensitivity.

I mean, they're not getting home with it alive.

Now, I will try the old medications from back in the 60s.

the morning oxidation inhibitors.

They work great.

In fact, work better than the alpha agonists.

They're just a royal pain to use.

And you have to be as old as I am to have ever been trained on them.

But they're still the very best antidepressants, very best anti-anxiety medications that have ever come on the market.

It's just, they're a pain.

They're difficult.

Why are they difficult?