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Dwarkesh (host)

๐Ÿ‘ค Speaker
244 total appearances

Appearances Over Time

Podcast Appearances

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And you see this allele.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You see that allele.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And then I guess evolution here is a maintainer, which is then driving one of them to fixation.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

The analogy for asexual reproduction, just cloning with mutation, would be, okay, you fork the repository.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

Then you make a random change.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You just change some random variable.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You change a word.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

You change a bit.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And almost every single time, this will be deleterious.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

Yeah.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And even when it's not deleterious...

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

there's no merge functionality.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

So these different, you've got millions of repositories that are then spawning millions of other repositories.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And even if some improvement has been made on one of them, there's no systematic way in which the improvements can be merged together.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

Yeah, and then finally, lateral gene transfer.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

So here's the analogy it might be.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

Okay, so you've got one repository for, let's say, editing web pages and another repository for controlling airline software.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And what you just do is you take a random 500-line sequence in this web page editing software, and you just put it in a random point in the airplane management software.

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

And there's no...

Dwarkesh Podcast
Nick Lane โ€“ Life as we know it is chemically inevitable

So then I guess, honestly, I don't really have good intuition for why lateral gene transfer does not produce similar benefits to recombination.