Dylan Gemelli

And that's why I want to talk to everybody specifically today about the effects of GLP-1 drugs on aging.

Now, this really takes us to understand redox biology and basic biochemistry.

our bodies run on what we call an electron flow.

So when we're looking at this, we have to understand that health is the maintenance of proper reduction oxidation balance.

So when that balance collapses, what happens?

aging acceleration.

So to make this a little bit broken down, both GLP-1 manipulation and chronic immune stimulation increase reactive oxygen species.

How?

Through iron oxidation.

So what happens is, is that iron, while it's in an oxidized state, becomes a catalyst for radical formation.

So those radicals damage proteins, lipids, and mitochondrial membranes.

So then what happens?

Well, the consequences actually show up downstream.

Bone loss, muscle loss, hormone decline, immune dysfunction.

Why does this happen?

Well, because iron-driven oxidative stress actually interferes with mineral balance and also mitochondrial function.

so calcium is extremely critical to mitochondrial enzymes and the rotational activity of atp synthase so then what happens well lower calcium availability slows enzymatic spin rate what then well the lower the spin rate the less atp production that we actually have so

When we have that lower ATP, it actually tells our body to then downshift metabolism.

How?

Through reduced thyroid signaling.