Elena Resnick

So it's four small pricks under the surface of the skin.

So it's four small pricks under the surface of the skin.

If you are allergic, we would expect that where we pricked you with the saline, nothing would happen. Where we pricked you with the histamine, you'll get a red itchy bump. And where we prick you with the penicillin, you will also get a red itchy bump. That's considered a positive test. We say you've tested positive for penicillin allergy. That's it. Go home. Continue to avoid penicillins.

If you are allergic, we would expect that where we pricked you with the saline, nothing would happen. Where we pricked you with the histamine, you'll get a red itchy bump. And where we prick you with the penicillin, you will also get a red itchy bump. That's considered a positive test. We say you've tested positive for penicillin allergy. That's it. Go home. Continue to avoid penicillins.

If you are allergic, we would expect that where we pricked you with the saline, nothing would happen. Where we pricked you with the histamine, you'll get a red itchy bump. And where we prick you with the penicillin, you will also get a red itchy bump. That's considered a positive test. We say you've tested positive for penicillin allergy. That's it. Go home. Continue to avoid penicillins.

If it's negative, we go on and do the intradermal test, which hurts a little bit more. We're using the same reagents, and we're putting them just under the surface of the skin. And again, we look to see, do those bumps get any bigger during the waiting period? And we're comparing them again against saline. If that test is positive, again, you go home. That's it. You're allergic.

If it's negative, we go on and do the intradermal test, which hurts a little bit more. We're using the same reagents, and we're putting them just under the surface of the skin. And again, we look to see, do those bumps get any bigger during the waiting period? And we're comparing them again against saline. If that test is positive, again, you go home. That's it. You're allergic.

If it's negative, we go on and do the intradermal test, which hurts a little bit more. We're using the same reagents, and we're putting them just under the surface of the skin. And again, we look to see, do those bumps get any bigger during the waiting period? And we're comparing them again against saline. If that test is positive, again, you go home. That's it. You're allergic.

But if that test is negative, we now have a skin prick and intradermal tests that are both negative. And the studies show that in those cases, it's 95% likely that you'll then pass a penicillin challenge. I think in real life, it's probably much, much higher than that. But we go ahead and we do an oral challenge, which is just what it sounds. We give you a dose of a penicillin.

But if that test is negative, we now have a skin prick and intradermal tests that are both negative. And the studies show that in those cases, it's 95% likely that you'll then pass a penicillin challenge. I think in real life, it's probably much, much higher than that. But we go ahead and we do an oral challenge, which is just what it sounds. We give you a dose of a penicillin.

But if that test is negative, we now have a skin prick and intradermal tests that are both negative. And the studies show that in those cases, it's 95% likely that you'll then pass a penicillin challenge. I think in real life, it's probably much, much higher than that. But we go ahead and we do an oral challenge, which is just what it sounds. We give you a dose of a penicillin.

We use amoxicillin, which is a common oral penicillin. We give you that dose. We have you wait in the office for about two hours just to make sure that you're fine. And that's the gold standard, right? Tests are tests. But if you take the medication and you're fine, then we know you're not allergic.

We use amoxicillin, which is a common oral penicillin. We give you that dose. We have you wait in the office for about two hours just to make sure that you're fine. And that's the gold standard, right? Tests are tests. But if you take the medication and you're fine, then we know you're not allergic.

We use amoxicillin, which is a common oral penicillin. We give you that dose. We have you wait in the office for about two hours just to make sure that you're fine. And that's the gold standard, right? Tests are tests. But if you take the medication and you're fine, then we know you're not allergic.

Atenosylins are an amazing drug also because we know them to be safe and effective in pregnancy. When a pregnant woman goes in to deliver, if she is colonized with group B strep, which is a very common vaginal infection, she must be given antibiotics before delivery to ensure that the baby is not exposed to the group B strep.

Atenosylins are an amazing drug also because we know them to be safe and effective in pregnancy. When a pregnant woman goes in to deliver, if she is colonized with group B strep, which is a very common vaginal infection, she must be given antibiotics before delivery to ensure that the baby is not exposed to the group B strep.

Atenosylins are an amazing drug also because we know them to be safe and effective in pregnancy. When a pregnant woman goes in to deliver, if she is colonized with group B strep, which is a very common vaginal infection, she must be given antibiotics before delivery to ensure that the baby is not exposed to the group B strep.

So the antibiotic of choice for group B strep is in the penicillin family. Mom comes in. She's ready to deliver. She gets a dose of penicillin. She gets her second dose four hours later. She delivers the baby. Everything is fine. If she is thought to be penicillin allergic, instead she's given vancomycin. Vancomycin dosing interval is every 12 hours.

So the antibiotic of choice for group B strep is in the penicillin family. Mom comes in. She's ready to deliver. She gets a dose of penicillin. She gets her second dose four hours later. She delivers the baby. Everything is fine. If she is thought to be penicillin allergic, instead she's given vancomycin. Vancomycin dosing interval is every 12 hours.

So the antibiotic of choice for group B strep is in the penicillin family. Mom comes in. She's ready to deliver. She gets a dose of penicillin. She gets her second dose four hours later. She delivers the baby. Everything is fine. If she is thought to be penicillin allergic, instead she's given vancomycin. Vancomycin dosing interval is every 12 hours.