Eric Topol

Do they already have a blood clot or do they already have breast cancer?

Can't we do better in separating out those people who are at risk so that we don't unknowingly treat them and induce a problem?

that's a scan for $75, you know, anywhere and no.

There's going to be thin people, never had extra weight, who are really prone to osteoporosis too.

Yeah, so instead of the U.S.

Preventive Task Force, like, for example, at Mass General Brigham,

They're giving patients in their health system these polygenic risk scores, like for breast cancer, you know, they're giving it, and for heart disease.

And, you know, you have two-fold risk or you have no increased risk.

Wouldn't that be helpful in general if those were widely available?

No, I think your point, just to clarify—

if you have a high polygenic risk for a condition, it doesn't say when.

You could have a high polygenic risk for Alzheimer's, but it could be manifest at age 99.

That doesn't really help you.

But I think we have increasing confidence after all these years, decades now of these, that they can be helpful, but they're not being used.

And certainly, they're not going to be recommended by the Preventive Task Force for the reasons that you've already mentioned.

Now, another big issue is how long do you use the therapy, MHT?

The rest of a person's life?

What do you say there?

All right.

So what if you have a woman who's, let's say, 12 plus years from menopause, never been on and would like to take a patch for whatever benefits it might be gleaned?