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Eric Topol

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
3037 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Is it kind of a precursor to it?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

How do you conceive this?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Because this is such a complex... I mean, it is the fundamental unit of life, but it's also so much more complex than a protein or an RNA because...

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

not only all the things inside the cell, inside all these organelles and nucleus, but then there's all the outside interactions.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So, this is a bold challenge, right?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Oh, absolutely.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Now, I think

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

You already mentioned something that's quite, well, two things from what you just touched on.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

One, of course, how vital it is to have this inner or interdisciplinary capability because you do need expertise across these vital areas.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

But the convergence, I mean, I love your term nodal biology and the fact that there's all these diseases like you were talking about, they do converge and nodal is a good term to highlight that.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

But

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

It's not, of course, as you mentioned, we have genome editing, which allows to look at lots of different genome perturbations, like the single letter change that you found in one pathogenic critical mutation.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

There's also the AI world, which is blossoming like I've never seen.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

In fact, you know, I had a science this week about

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

learning the language of life with AI and how there's been like 15 new foundation models, DNA, proteins, RNA, ligands, all their interactions and the beginning of the cell story too with the human.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So, this is exploding.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And so, as you said, the expertise in computer science.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And then, this whole idea that you could take these powerful tools

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

and do, as you said, which is the need to accelerate.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

We just can't sit around here when there's so much discovery work to be done with the scalability.