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Eric Topol

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
3037 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And then you switched gears.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So tell us about that.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Well, I think that's perfect.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Curiosity driven science is not the term you often hear hypothesis driven, or now with AI, you hear more AI exploratory science, but, you know, no, that's great.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Now,

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

I want to get a little back to the AI story because it's so fascinating.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

You use lots of different types of AI, such as cellular imaging, would be fusion models and drug discovery.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

I mean, you've had drug discovery for different pathways.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

You mentioned, of course, the ion channel.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

And then also, as we touched on with your cell paper, the whole idea of

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

of targeting the cargo receptor with a small molecule, and then things in between.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

So can you kind of, you discussed this, of course, at the London panel, but maybe you just give us the skinny on the different ways that you incorporate AI in the state of the art science that you're doing.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Oh, no question.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Now, it must be tough when you know the mechanism of these families' disease and you even have a drug candidate, but that it takes so long to go from that to helping these families and

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

What are your thoughts about that?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

I mean, are you thinking also about genome editing for some of these diseases, or are you thinking to go through the route of, you know, here's a small molecule, here's the tox data in animal models, and here's phase one, and on and on?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

Where do you think, because when you know so much, and then these people are suffering, how do you bridge that gap?

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

I have no doubts that you'll be doing this many times in your career.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

No, there's no question about it.

Ground Truths
Anna Greka: Molecular Sleuthing for Rare Diseases

It's extraordinary, actually.