Eric Topol

Now, going back to Priscilla's point, we're talking about thousands of different rare Mendelian genomic disorders, thousands of them.

And if you add them all up of rare diseases, we're talking about hundreds of millions of people affected around the world.

So this is a foray into something much bigger, no less the fact that some of these rare mutations are shared by common diseases and approaches.

So this is really big stuff.

Congratulations to both of you and your organizations, the Innovative Genomics Institute and the Chan Zuckerberg Initiative for taking this on.

We'll be following it with very deep interest.

Thank you.

Hello, it's Eric Topol from Ground Truths, and I am really delighted to welcome Adam Kucharski, who is the author of a new book, Proof, a distinguished mathematician, by the way, the first mathematician we've had on Ground Truths, and a person who I had the real privilege of getting to know a bit through the COVID pandemic.

So welcome, Adam.

Thanks for having me.

Yeah, I mean, I think just to let everybody know, you're a professor at London School of Hygiene and Tropical Medicine.

And also noteworthy, you won the Adams Prize, which is one of the most impressive recognitions in the field of mathematics.

This is the book.

It's a winner proof.

And there's so much to talk about.

So Adam, maybe what I'd start off is the quote in the book that kind of captivates in the beginning.

Life is full of situations that can reveal remarkably large gaps in our understanding of what is true and why it's true.

This is a book about these gaps.

So what was the motivation when you undertook this very big endeavor?

Yeah, well, I mean, I think these times, of course, have really gotten us to appreciate, particularly during COVID, the importance of understanding uncertainty.