Erin Allman-Updike

So that's the first challenge is identifying those areas that need restoration, that we need to do something.

Otherwise, that repair process is not going to be able to start.

That's the first challenge.

Right.

The second challenge is that all of the surrounding tissue will have a lot of inflammation, right?

Because our body knows that something is going on and they're trying really hard to send in all the troops.

That means in the surrounding areas, we have a lot of vasodilation, right?

That means our blood vessels are getting larger, and that's to accommodate more flow.

We see an increase in vascular permeability.

So that means that our blood vessels are more leaky, and that is to allow all of the plasma that has our white blood cells and the inflammatory markers and the cytokines and all these things into the area to try and help.

But unfortunately, what that ends up resulting in is a lot of edema.

So a lot of fluid in the area because the degree of inflammatory signals is so high.

And this can be in and of itself very dangerous, especially in the event of like a circumferential burn.

So think like a burn that goes around your entire arm, for example.

Basically, the fluid has nowhere to go.

And so that's going to increase pressure in that area.

Does that make sense?

Yes.

How does blood pressure overall play?

Like what happens to your blood pressure?