Ezra Klein

You're a Hollywood celebrity with a personal chef versus you're a single mother of four who works two jobs.

And this idea that willpower is some unchanging muscle inside the mind as opposed to some reserve discipline that gets depleted.

Like, if I don't sleep enough, I eat more.

So one thing I've really appreciated about your work on the GLP-1s as a reporter and as somebody who's very deep in the science is you've done a tremendous amount of interviewing people on them.

And you've interviewed many of the kinds of people – and again, to me, this has always been the cruelty of this conversation – who were exercising a tremendous amount of constant willpower, going on and off, like, very restrictive diets, you know, losing 30 pounds, gaining it back –

What is it like for them, for the people who've seen huge amounts of weight loss?

How do they describe the experience of being on a GLP-1 versus what it's like off of one?

You said a second ago, for whom the drugs are effective.

For whom are they effective and for whom aren't they effective and why?

Tell me about the side effects of these GLP-1 drugs.

In studies, people often don't stay on them that long.

People do cycle off of them, sometimes for cost, but sometimes for other reasons.

What is unpleasant on them?

What can go wrong?

You just feel hungrier again?

The sort of appetite resets?

I've heard this, and it's definitely true in the data, but I guess people in my life have chronic conditions and the drugs are on.

They just have to stay on them.

You stop taking statins and the effect goes away.

If you're a diabetic, you have to keep taking your insulin.