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George Church

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
710 total appearances

Appearances Over Time

Podcast Appearances

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

And we know how to

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

We know the genes involved and we know how to do genetic counseling in some cases, gene therapy and other therapies to deal with it.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

At the other end, you know, we have

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

reduction of cognitive decline by cognitive enhancement, which is showing some promise.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

But again, that's kind of like this early stage severe impediment to cognition has a late stage component.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

But what about...

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

How much information does it take to encode a brain?

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

I'm not sure that that much less genome is required than if you just wanted to make a brain, because the brain is totally entangled with the body.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

You know, you have a 10 to the 11th neurons, 10 to the 14th synapses.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

If you wanted to reproduce a particular brain, let's say, it might be...

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

It's speculative as to whether it would be easier to do that by making a copy of it in silico, in some kind of inorganic matrix, or making a copy of it.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

Both of those are going to be hard.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

I would say that if you wanted to make a copy of a

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

you know, complicated book, it would be easier to take photographs of each of the pages than to completely translate it into another language, trying to get all the nuances and the poetry and so forth if your goal is just to replicate it.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

And I think the same thing might be true of a brain.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

But replicating a brain probably involves a lot more information than synthesizing it.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

So, I mean, just to define the 10 to the 14 synapses is going to take a lot more bytes than the genome, which is

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

billions rather than 10 to the 14th.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

But there might be reasons that you want to replicate a particular brain configuration rather than just make another animal that starts from scratch as an infant.

Dwarkesh Podcast
George Church โ€” A Billion Years of Evolution in a Single Afternoon

Well, I mean, certain things seem incompatible, like the temperatures of a fission reactor.