Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Blog Pricing

Helen MacDonald

๐Ÿ‘ค Speaker
See mentions of this person in podcasts
1132 total appearances

Appearances Over Time

Podcast Appearances

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

So I put it out to you.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

What do you think, Duncan and Carl?

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

Have you ever said that to a patient, Carl?

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And in fact, they suggest that the additional reduction is totally unmeasurable.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And this paper has been quite well picked up on Twitter and I think it was on Twitter I read one of the comments or a suggestion which I thought was quite helpful was that wouldn't it be interesting if test results came with that biological variation kind of marked around them so as you're plotting or looking at people's test results to see how they've changed over time to try and be able to see if that change is clearly meaningful or potentially just

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

I left behind in that table all the results, which I never dwell on in detail.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

I'll take over.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

Well actually I'll pause on the conflicts of interest for a moment because something that interests me possibly even more than conflicts of interest is I love interviewing authors and I've interviewed lots of authors over the years about their research and I have often found that the most interesting question you ask them and it's sometimes Duncan it's when you're up in the little studio setting things up and I say things like oh this is very informal

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

Why don't you just tell me, why did you do this in the first place?

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And I think it's such a fascinating question.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And you so rarely find the answer to that question in the background of any research paper.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And I like this paper, not just because it's about conflicts of interest, but because I think it's a really fascinating story.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And the paper's senior author, who's a professor of dermatology, called Eleni Linos,

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

told Duncan a bit about her story.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

So back in 2012, she published a systematic review and meta-analysis which pooled evidence and showed that sunbeds and UV exposure was linked to melanoma and other non-melanoma skin cancer's

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And it seemed to sort of go out there and be reasonably uncontroversial.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

Yeah, it's not particularly surprising.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

But several years later, she got a critical response to her paper online, which made her go back and double check the science and check that, you know, everything was in order, which it was.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And she started thinking about why this happened.

Talk Evidence
Talk Evidence - testing under the microscope and opioid prescription

And I think we should listen to Eleni talk about her puzzlement about this response to her paper.