Talk Evidence - testing under the microscope and opioid prescription

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Talk Evidence 54 min 5 speakers 8 chapters transcribed
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What are the patterns of opioid prescribing among clinicians?

Duncan Jarvis 0:10
Welcome back to Talk Evidence, your monthly look at the world of EBM. I'm Duncan Jarvis, multimedia editor here at the BMJ. As always, I'm joined by Helen and Carl, who've both made it into the studio today. Carl, can I get you to introduce yourself?
Carl Heneghan 0:26
Yes, hi, I am Carl Hennigan. I'm editor-in-chief of BMJ Evidence-Based Medicine and professor of EBM at the University of Oxford and a general practitioner.
Duncan Jarvis 0:36
And Helen.
Helen MacDonald 0:38
I'm Helen MacDonald.

How can absolute numbers improve the presentation of lung screening data?

Helen MacDonald 0:39
I'm the UK research editor for the BMDA and arresting GP.
Carl Heneghan 0:44
I like how you've stuck with that.
Helen MacDonald 0:45
Yeah, I have. I think it suits me well.
Carl Heneghan 0:47
I think, though, with the coronavirus, you may have to... I might be called up.
Helen MacDonald 0:50
They might be desperate enough that they'll call me back immediately.
Duncan Jarvis 0:59
This week we are going to be doing some starting and some stopping. Helen, shall we start with you?
Helen MacDonald 1:07
Yes, I wanted to talk about an interesting paper which was published in the BMJ back at the end of January, actually.

What is the impact of dietary sodium reduction on blood pressure?

Helen MacDonald 1:15
And I think this is a start, maybe to start looking at your opioid prescribing in chronic pain. And the background is that prescription opioids are a big problem. They cause iatrogenic harm in some cases. And in the US, this is an even bigger problem than in some other parts of the world.

Why do test results vary and how should they be interpreted?

Helen MacDonald 1:34
And the authors of this particular research paper say that in order to educate and support prescribers, we really need to understand who's prescribing and what their patterns of prescribing are. So they did this retrospective study in a big US healthcare insurance system between 2003 and 2017, looking at the volume and patterns of prescriptions by provider. By provider, I think they mean a single person, but I could be wrong. And what they find is that things are very skewed. And what seemed astounding to me was that they said the top 1% of prescribers accounted for essentially half of all of the opioid doses and about 27% of all of the opioid prescriptions. And they felt quite confident in these findings because it's a big study.
Helen MacDonald 2:20
It's national. It was over a long time period. They did lots of clever adjustments accounting for the prescription length and the number of people people see and the number of prescriptions they do. And over time, these high prescribers seemed like a stable group of people in this kind of countrywide phenomenon.
Duncan Jarvis 2:40
So there's that whole like atlas of variation thing that said that, you know, you get these pockets of the way people do medicine. So, you know, whatever it is, sending people for MRI can be quite a localised thing.

What do conflicts of interest in tanning research mean for public health?

Duncan Jarvis 2:55
Was there any data about who these people were? Yeah. Were they clustered?
Helen MacDonald 3:00
They did. They said, and it's hard to infer. to interpret in some ways, but more than half of that top centile of prescribers were in family medicine, so about 24%, or in physical or pain medicine and rehabilitation. That was about 14% of them. Anesthesiology and internal medicine. So in some ways you think, well, that's kind of justified because those people are probably the people that are dealing with chronic pain. But at the same time, they sort of make a suggestion that not all of that prescribing can be So they say that those top prescribers are consistently prescribing well above the CDC recommended opioid doses and durations for the management of chronic pain. So they think that there's something unusual about that group of people.
Helen MacDonald 3:49
And it's quite interesting because I like the way that they try to apply this to then what should happen in the real world. And their suggestion is that with this top centile, there's clearly a group of people that have sustained high prescribing over time and their patients are perhaps at the highest risk of harm. So they suggest that those are the target clinicians or maybe they're not clinicians, they're healthcare services, whatever provider means in this paper.

What issues arise from smartphone apps for skin cancer diagnosis?

Helen MacDonald 4:14
They're the places to target for education and support for clinicians on prescribing. And that might be a better approach if you want to minimise inappropriate prescribing than just targeting blanket education initiatives at everybody. Because it actually seems to be a much smaller proportion of prescribers who are doing that work.

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