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Jack Ashby

๐Ÿ‘ค Speaker
530 total appearances

Appearances Over Time

Podcast Appearances

Conversations
Encore: The misfit mammal that defies biological conventions

So they're fighting each other and envenomating each other because if it were used for defence, we'd expect the females to be venomous too, but they are not.

Conversations
Encore: The misfit mammal that defies biological conventions

That's such an odd thing to say.

Conversations
Encore: The misfit mammal that defies biological conventions

It's extraordinary.

Conversations
Encore: The misfit mammal that defies biological conventions

I was about to say the venom is unlike any other venom on Earth, but the opposite is true.

Conversations
Encore: The misfit mammal that defies biological conventions

The cocktail is unlike anything else on Earth, but actually they've evolved venom that is almost โ€“ they've got maybe 20 or so different venom compounds โ€“

Conversations
Encore: The misfit mammal that defies biological conventions

But each of those compounds have evolved convergently with the venom that's seen in centipedes, frogs, fishes, snakes, spiders, jellyfish.

Conversations
Encore: The misfit mammal that defies biological conventions

So they've kind of got the best bits of venom from the animal kingdom.

Conversations
Encore: The misfit mammal that defies biological conventions

And of course, this isn't how evolution works.

Conversations
Encore: The misfit mammal that defies biological conventions

They've taken them together and made a super cocktail.

Conversations
Encore: The misfit mammal that defies biological conventions

And not many people have recorded being stung by a platypus.

Conversations
Encore: The misfit mammal that defies biological conventions

Those that have done have described an excruciating pain that can last for months, literally months, and then muscle wastage that goes on for decades.

Conversations
Encore: The misfit mammal that defies biological conventions

So people have been unable to regain movement for, you know, I think one report I can think of that can specify a natural number is 15 years.

Conversations
Encore: The misfit mammal that defies biological conventions

still couldn't move their hands properly.

Conversations
Encore: The misfit mammal that defies biological conventions

And that is because one of these compounds is extraordinarily stable.

Conversations
Encore: The misfit mammal that defies biological conventions

So it just doesn't break down.

Conversations
Encore: The misfit mammal that defies biological conventions

And that may be why platypus venom lasts so long.

Conversations
Encore: The misfit mammal that defies biological conventions

So yes, in answer to your question, those compounds could be potentially very useful for pain reduction and just how do pain receptors work in humans.

Conversations
Encore: The misfit mammal that defies biological conventions

Yeah, so it happened a while ago.

Conversations
Encore: The misfit mammal that defies biological conventions

It probably happened about 50 million years ago, but echidnas evolved from a platypus ancestor.

Conversations
Encore: The misfit mammal that defies biological conventions

The oldest fossil we have, I think, is only 15 million years, but genetics suggest 50 million.