Menu
Sign In Search Podcasts Charts People & Topics Add Podcast API Blog Pricing

James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So they don't have, exactly.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

They don't have their own machinery to be able to replicate.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

They have to use the host cells machinery.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And so firstly, they'd probably struggle to even bind to the surface of the mirror bacterium, but let's say they could and they inject their genetic material.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

into the myrobacterium, that genetic material won't be read by the host cell.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So the ribosome in the myrobacterium won't translate any RNA into proteins or the transcription of the DNA won't work.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So they would be completely immune to this.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And this is something we can be very, very confident in.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It's basically 100%.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So why that's important is because this is a really common source of death for bacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So if they aren't going to be subject to this, they're getting a massive fitness advantage.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And that means they might actually be able to spread in the environment and outcompete other bacterial species as well.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So they might be able to grow in soil.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Well, they might be able to grow in the oceans as well as infecting all of these different species that we talked about already.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So we can be very confident that the bacteriophage won't work.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

There are a bunch of other predators that normally eat up bacteria too.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

These include amoebae or protists, which basically work like macrophages in the immune system.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

They engulf their prey and many mechanisms in that process