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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

of engulfing prey and then killing it depend on interactions that probably wouldn't work with myrobacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Of course they do.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Classic, right?

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So I think a lot of protists are unlikely to want to consume myrobacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Even if they could, it's not clear they're going to get much nutritional value from them.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So they might actually evolve away from them rather than towards wanting to do this in the first instance.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So major sources of predation, including infection by viruses, but also consumption by protists or amoebae, are probably not going to happen.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I think eventually, yes, that would happen.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It would probably still take a long time.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So bacteriophage are effectively never going to evolve to be able to do this because they'd have to switch their whole genetic code around.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And that's a massive evolutionary step.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But other predators like protists could eventually evolve to do this.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I think it's actually more likely.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And I should say this is an area where...

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

the dynamics would be so complex that it's difficult to reason confidently about it.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But I think we can make some guesses.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Protists initially might actually evolve to not want to consume myriobacteria when they're only present at low concentrations in the environment, because they're probably not going to get much nutritional value from them initially.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So the first few protists that accidentally eat up myriobacteria

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

the myrrh bacteria might end up being toxic to the protist.