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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

It is really cool.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I'm extremely sympathetic.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And I think it makes complete sense that people wanted to do this.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But the amazing thing is that the people who did want to do this are on the paper who come forward and said that it's not something they think should be done.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So the people who were most interested in doing this stuff are now the ones that are saying that it shouldn't be done.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And I think that's just a pretty amazing story.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, I mean, so unless new evidence comes out that really changes this picture, I think three things would need to be true in the next, say, two to five years for me to feel comfortable that the mirror life problem was basically solved.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The first is that I think there needs to be a strong norm against the work to make mirror life in the scientific community.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The second is that I think there needs to be regulation of enabling technologies or precursor technologies, the things that we develop on the way to making mirror life.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And then the third is that governments need to be taking this seriously such that they would deploy the kinds of capabilities that they use to stop terrorists from accessing nuclear weapons to the question of mirror life.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Yeah, I think on the norm against mirror life, there's already been quite good progress.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So UNESCO, for example, have recently put out a report from their International Bioethics Committee recommending a global moratorium on mirror cells.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The UK government has looked into this and

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

written up some notes saying that they think mirror life creation should be prevented.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

This German expert committee has looked into it and kind of endorsed the analysis of the risks.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So I think there's already quite good momentum on that point.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The second point, which is around the enabling technologies, that I think is a much more difficult

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

decision um and the reason is because some of those technologies are things that people might want to work on in the near term so you mentioned mirror enzymes but actually people can already make quite a lot of mirror enzymes and most of that i think is is completely fine yeah there's there's no reason to need to go back and try to do anything about work that's that's already been done

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But there are things that could be done in, say, the next six months or the next couple of years that some people think should not be pursued.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

One example there is the mirror ribosome.