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James Smith

๐Ÿ‘ค Speaker
922 total appearances

Appearances Over Time

Podcast Appearances

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I think it could be great for people to be making more mirror environments, putting bacteria in them, seeing how they survive.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But the data that we have at the moment suggests that this is not going to be a problem.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I think it's possible.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I mean, if there was a myrobacteria outbreak, then I'm sure it would make sense to try stuff like this.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

I don't think it would be a very good preventive measure because I'm sure there would be other impacts that we haven't thought about of changing the whole of the world's ecosystem in one go.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And I actually think there are probably more promising countermeasures that would kind of spread on their own that might be worth talking about more.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So mirror phages are one example.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

We talked about phages already, which are the viruses that infect bacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Normal phage wouldn't be able to infect mirror bacteria because the mirror bacteria can't read the genetic code of the phage.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But you could synthetically make a mirror phage or a mirror virus that would be able to infect mirror bacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Phage are one of the main things in the wild that kill bacteria and they replicate when they kill the bacteria.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

So you could use this as a way to control the population of myrobacteria to some extent.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

The difficulty is that you can't use them to completely wipe out a myrobacteria population because you need a certain density of the host population for the phage to be able to replicate.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

Exactly.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

You end up getting these kind of population dynamics where the prey population will drop.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

That then means that the predator population drops, which then means that the prey population can expand again, which then causes the predator population to expand.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And so you end up with this kind of like up and down trend.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

But it's very difficult to completely eliminate a host species in this way.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

And we've never been able to use a biological control to completely eliminate.

80,000 Hours Podcast
Why I quit everything to work on a biothreat nobody had heard of | James Smith, Mirror Biology Dialogues Fund

make extinct a species that we've tried to do this with.