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Jason Crawford

👤 Person
753 total appearances

Appearances Over Time

Podcast Appearances

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

Later in his career in the 1880s, when he was doing experiments on farm animals to try to figure out what

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

diseases that they would get.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

This picture is of a rabbit, but it was actually, he was doing experiments with chickens and something called chicken collar.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

Through a botched experiment, his lab accidentally discovered how to make a vaccine.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And he discovered the mechanism of what is known as attenuated, live attenuated vaccines.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And he immediately realized the importance of this.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

He realized that he had been able to do, by accident, through a botched experiment, what no one had done since Jenner.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

For generations, for almost 90 years, no one had been able to come up with a vaccine for another disease beyond smallpox, and here he had accidentally done it in the last year.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And he immediately pivoted his attention to that, started creating vaccines for chicken cholera, for anthrax, which affected sheep, for a disease called swine erysipelas.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And then he created the first engineered vaccines in humans, beginning with rabies.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And when word got out, by the way, that he had even a potential rabies vaccine, patients started flocking to his office.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

People who'd been bitten by rabid animals and knew that they were at risk of developing rabies, which is a slow moving, a very slow developing disease, by the way.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

It takes like a month to really show symptoms and kill you.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And so it's one of the few diseases, by the way, where you can actually benefit by getting the vaccine after you've been exposed.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

Um, and so people had been bitten by, you know, rabid dogs and animals started coming into him and say, I heard you have a vaccine.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

Please save my son, save my child, save my life.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

And so, um, uh, pastor was very reluctant at first, especially when he'd never tested, you know, or it hadn't sufficiently tested the vaccine.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

Um, he gave the rabies vaccine to a child who doctors assured him had been bitten so much that he was a goner anyway, save the child's life.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

More people come and pastor realizes that, um, he's got to set up a clinic.

Astral Codex Ten Podcast
[Meetup Audio] Jason Crawford: "The Non-Linear Model of Innovation"

He's got to scale this up.