Jason Wachub

dr saranya wiles is a dermatologist regenerative medicine scientist and the director of regenerative dermatology and skin longevity lab at the mayo clinic her research sits at the cutting edge of aging biology looking at how cellular senescence wound healing inflammation and regenerative therapies shape not only how our skin looks but how it functions as a true longevity organ

In today's show, we'll dive into some fascinating topics, including how your skin reflects systemic aging and why it may be your most visible biomarker of long-term health.

We also cover what zombie cells actually are and how they accelerate both skin aging and whole body aging as well.

Plus, you'll learn about the five pillars of skin longevity and the future of regenerative dermatology.

This episode is packed with actionable insights.

Let's dive in.

So you started in dermatology and regenerative medicine.

What shifted your focus from aesthetics toward the deeper biology of aging skin?

And so how does one get a sense of how their skin is aging?

And so with melanocytes specifically, is there anything we can proactively do to stop this from happening or potentially reverse the damage?

So zombie cells, how do they accumulate?

Why do they matter?

I think this larger idea of it's not just about your skin health.

It's not just for aesthetics like the wrinkles.

But can you talk about zombie cells and what this looks like in terms of overall skin health and systemic aging more generally?

Because I think it's just this idea that

So if we don't want that to happen, what should we do?

Are there therapies available to us?

Is there anything beyond the common sense of don't smoke, don't expose yourself to high UV during peak UV times during the day?

How do you think about that?