Jeff Krasno

So hemoglobin is that little protein in the red blood cells that takes the oxygen and goes, okay, here we're going off to the blood cells. And if it's more likely to release it, that's better for energy production. So this is just like one of hundreds and hundreds of sort of pre-programmed adaptive responses to stress that exist in the human body.

But we've largely stripped all of those stressors out of the way that we live. So like, for example, like nutrient deficiency or calorie restriction is actually totally adaptive. It's really good for us. Not only does it keep... Andre nice and lean and lithe and a wonderful figure.

But we've largely stripped all of those stressors out of the way that we live. So like, for example, like nutrient deficiency or calorie restriction is actually totally adaptive. It's really good for us. Not only does it keep... Andre nice and lean and lithe and a wonderful figure.

But we've largely stripped all of those stressors out of the way that we live. So like, for example, like nutrient deficiency or calorie restriction is actually totally adaptive. It's really good for us. Not only does it keep... Andre nice and lean and lithe and a wonderful figure.

But also, it's activating certain metabolic pathways and other enzymes, et cetera, within your body. You know, there's a lot of scientists and medical experts wonks talk about like AMP kinase or whatever, these pathways for restoration and repair in the human body that stimulate these processes like autophagy and cellular cleanup and all this kind of stuff.

But also, it's activating certain metabolic pathways and other enzymes, et cetera, within your body. You know, there's a lot of scientists and medical experts wonks talk about like AMP kinase or whatever, these pathways for restoration and repair in the human body that stimulate these processes like autophagy and cellular cleanup and all this kind of stuff.

But also, it's activating certain metabolic pathways and other enzymes, et cetera, within your body. You know, there's a lot of scientists and medical experts wonks talk about like AMP kinase or whatever, these pathways for restoration and repair in the human body that stimulate these processes like autophagy and cellular cleanup and all this kind of stuff.

These processes were developed in relation to sort of paleolithic stress because in the olden days, you know, back in our hunter-gatherer days on the Serengeti, There would be a calorie paucity as part of winter, right? But now we live in this age where winter never really comes. So it's all calorie abundance all of the time. So the body is just really doing what it's meant to do.

These processes were developed in relation to sort of paleolithic stress because in the olden days, you know, back in our hunter-gatherer days on the Serengeti, There would be a calorie paucity as part of winter, right? But now we live in this age where winter never really comes. So it's all calorie abundance all of the time. So the body is just really doing what it's meant to do.

These processes were developed in relation to sort of paleolithic stress because in the olden days, you know, back in our hunter-gatherer days on the Serengeti, There would be a calorie paucity as part of winter, right? But now we live in this age where winter never really comes. So it's all calorie abundance all of the time. So the body is just really doing what it's meant to do.

It just stores fat away, you know, for a rainy day. But then there's no rainy day. And so this is like...

It just stores fat away, you know, for a rainy day. But then there's no rainy day. And so this is like...

It just stores fat away, you know, for a rainy day. But then there's no rainy day. And so this is like...

I think one of the greatest tensions that exist in modernity are these evolutionary mismatches, where we essentially evolved for a certain amount of stress, but since the Industrial Revolution and really accelerating over the last 50 or 70 years, we've engineered our lives at every single turn, often in the name of profit,

I think one of the greatest tensions that exist in modernity are these evolutionary mismatches, where we essentially evolved for a certain amount of stress, but since the Industrial Revolution and really accelerating over the last 50 or 70 years, we've engineered our lives at every single turn, often in the name of profit,

I think one of the greatest tensions that exist in modernity are these evolutionary mismatches, where we essentially evolved for a certain amount of stress, but since the Industrial Revolution and really accelerating over the last 50 or 70 years, we've engineered our lives at every single turn, often in the name of profit,

for ease and convenience and that ease is creating a lot of dis-ease and that convenience is creating candidly a lot of inconvenient truths that we have to grapple with.

for ease and convenience and that ease is creating a lot of dis-ease and that convenience is creating candidly a lot of inconvenient truths that we have to grapple with.

for ease and convenience and that ease is creating a lot of dis-ease and that convenience is creating candidly a lot of inconvenient truths that we have to grapple with.

Yeah.