Jonathan Jarecki

And then another piece of evidence that they highlight in this new paper that we're about to discuss, when we look at the pancreas of type 2 diabetics,

And we can look at the islets.

Islets in a pancreas are basically, you can think of them as these sort of like pockets where things like insulin gets secreted.

And we look at these islets.

The islets, again, they have a circadian rhythm to them.

When we look at the islets of type 2 diabetics, the pancreas, right?

When we look at the islets of the type 2 diabetics, we see...

a decrease in the amplitude of circadian clock genes.

We have these clock genes which are circadian in nature, so they get expressed at certain times of the day and they get suppressed at other times of the day.

We see a reduced amplitude.

That tells us that there is something wrong from a circadian perspective happening in those islets in the pancreas.

We also see a reduced capacity to synchronize the circadian clock of these islets.

And what's really fascinating is that if we add in a synthetic molecule to these islets that basically modulate the circadian system

and reinforce the circadian system synthetically, we can actually see an increase in insulin secretion, so an improvement in insulin secretion.

And that's a synthetic improvement, we're improving it synthetically, but how do we reinforce the circadian clock naturally in our lives?

Well, we get out in sunlight and we synchronize our clock with the natural rhythm of the light, of sunlight.

And so those are really three interesting pieces of evidence that they point in this study.

And now we have this brand new study out that looks at humans in a controlled lab.

What they did basically was they had people, there were 13 participants, so small sample size, but nevertheless, a really, really fascinating study.

And it should at the very least prompt us to question and to ask, hey, we need more research on this.