Jonathan Jarecki

These women were living longer lives.

And that dose-dependent curve doesn't prove causation, right?

But it does validate the correlation that we see a little more.

We have that really interesting study that these women, right, who are getting more sun exposure are dying less frequently than those with the least amount of sun exposure.

And they also looked at smoking habits of these women.

Yeah, this is crazy.

What they showed is that those women who got the most amount of sun exposure but also smoked had the same mortality as those women who didn't get sun exposure but smoked.

So those women who got the most amount of sun exposure and did not smoke died at the same rate as those women who didn't get sun exposure but smoked, showing that basically sun exposure habits are on the same playing field

as smoking right so it's pretty mind-blowing right when we look at smoking right we we it's pretty well known that smoking causes lung cancer right but we don't actually have a randomized placebo-controlled trial of women who smoke and who don't smoke we can't just tell all right you you group you go smoke and then you guys don't smoke and let's see your outcomes right we don't have that because let's follow you for like 50 years and let's see what happens we don't actually have that data

We don't have that data.

That's unethical, right?

What we have is correlational studies.

And the correlation is so strong, right?

We have a dose-dependent curve.

We have a very strong correlation.

Then we also have, you know, animal models and more in vitro cell models.

And we see the same outcomes, right?

But even with smoking, right?

We don't have a causal...

a randomized placebo-controlled trial study of smoking causes lung cancer, but we say it causes it because we have such a strong correlation.