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Lee Cronin

๐Ÿ‘ค Speaker
1635 total appearances

Appearances Over Time

Podcast Appearances

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Some people call it negentropy. Some people think about organizational principles. Lots of people were not shocked by the paper because they'd done it before. A lot of the arguments we got, some people said, oh, it's rubbish. Oh, by the way, I had this idea 20 years before. I was like... Which one? Is it the rubbish part or the really revolutionary part?

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Some people call it negentropy. Some people think about organizational principles. Lots of people were not shocked by the paper because they'd done it before. A lot of the arguments we got, some people said, oh, it's rubbish. Oh, by the way, I had this idea 20 years before. I was like... Which one? Is it the rubbish part or the really revolutionary part?

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So this kind of plucked two strings at once. There is something interesting that biology is, as we can see around this, but we haven't quantified yet. And what this is, the first stab at quantifying that. So the fact that people said, this is obvious, but it's also... So if it's obvious, why have you not done it?

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So this kind of plucked two strings at once. There is something interesting that biology is, as we can see around this, but we haven't quantified yet. And what this is, the first stab at quantifying that. So the fact that people said, this is obvious, but it's also... So if it's obvious, why have you not done it?

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So this kind of plucked two strings at once. There is something interesting that biology is, as we can see around this, but we haven't quantified yet. And what this is, the first stab at quantifying that. So the fact that people said, this is obvious, but it's also... So if it's obvious, why have you not done it?

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, well, I think you will be able to. We just haven't got there robustly. So we can say, how can we... Let's go up a level. So if we go up from level, let's go up from molecules to cells because you jump to people and I jump to emoticons and both are good and they will be assembled.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, well, I think you will be able to. We just haven't got there robustly. So we can say, how can we... Let's go up a level. So if we go up from level, let's go up from molecules to cells because you jump to people and I jump to emoticons and both are good and they will be assembled.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, well, I think you will be able to. We just haven't got there robustly. So we can say, how can we... Let's go up a level. So if we go up from level, let's go up from molecules to cells because you jump to people and I jump to emoticons and both are good and they will be assembled.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Good point. If we go from... So if we go from molecules to assemblies, and let's take a cellular assembly, a nice thing about a cell is you can tell the difference between a eukaryote and a prokaryote, right? The organelles are specialized differently. We then look at the cell surface, right? and the cell surface has different glycosylation patterns, and these cells will stick together.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Good point. If we go from... So if we go from molecules to assemblies, and let's take a cellular assembly, a nice thing about a cell is you can tell the difference between a eukaryote and a prokaryote, right? The organelles are specialized differently. We then look at the cell surface, right? and the cell surface has different glycosylation patterns, and these cells will stick together.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Good point. If we go from... So if we go from molecules to assemblies, and let's take a cellular assembly, a nice thing about a cell is you can tell the difference between a eukaryote and a prokaryote, right? The organelles are specialized differently. We then look at the cell surface, right? and the cell surface has different glycosylation patterns, and these cells will stick together.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Now let's go up a level with multicellular creatures. You have cellular differentiation. Now, if you think about how embryos develop, you go all the way back, those cells undergo differentiation in a causal way that's biomechanically a feedback between the genetics and biomechanics. I think we can use assembly theory to apply to tissue types. We can even apply it to different cell disease types.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Now let's go up a level with multicellular creatures. You have cellular differentiation. Now, if you think about how embryos develop, you go all the way back, those cells undergo differentiation in a causal way that's biomechanically a feedback between the genetics and biomechanics. I think we can use assembly theory to apply to tissue types. We can even apply it to different cell disease types.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Now let's go up a level with multicellular creatures. You have cellular differentiation. Now, if you think about how embryos develop, you go all the way back, those cells undergo differentiation in a causal way that's biomechanically a feedback between the genetics and biomechanics. I think we can use assembly theory to apply to tissue types. We can even apply it to different cell disease types.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So that's what we're doing next. But we're trying to walk... You know, the thing is, I'm trying to leap ahead. I want to leap ahead to go, whoa, we apply it to culture. Clearly, you can apply it to memes and culture. And we've also applied assembly theory to CAs. And not as you think.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So that's what we're doing next. But we're trying to walk... You know, the thing is, I'm trying to leap ahead. I want to leap ahead to go, whoa, we apply it to culture. Clearly, you can apply it to memes and culture. And we've also applied assembly theory to CAs. And not as you think.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

So that's what we're doing next. But we're trying to walk... You know, the thing is, I'm trying to leap ahead. I want to leap ahead to go, whoa, we apply it to culture. Clearly, you can apply it to memes and culture. And we've also applied assembly theory to CAs. And not as you think.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, yeah, cellular automata. Not just as you think. Different CA rules were invented by different people at different times. And one of my coworkers, very talented chap, basically was like, oh, I can realize that different people had different ideas with different rules. And they copied each other and made slightly different cellular automata rules and looked at them online.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, yeah, cellular automata. Not just as you think. Different CA rules were invented by different people at different times. And one of my coworkers, very talented chap, basically was like, oh, I can realize that different people had different ideas with different rules. And they copied each other and made slightly different cellular automata rules and looked at them online.

Lex Fridman Podcast
#404 โ€“ Lee Cronin: Controversial Nature Paper on Evolution of Life and Universe

Yeah, yeah, cellular automata. Not just as you think. Different CA rules were invented by different people at different times. And one of my coworkers, very talented chap, basically was like, oh, I can realize that different people had different ideas with different rules. And they copied each other and made slightly different cellular automata rules and looked at them online.