Marisa

All the models also pointed out that the ACE model is a simplification and that gene-environment interaction may be significant.

These are pretty wide error bars.

But since A is trying to capture heredity only, we can take A as a rough lower bound for biological causation.

Even if E is purely social, 38% is significant.

Also, none of this tells us how much variation there is at the individual level.

And we have no trans-GWAS.

The big question is whether E is dominated by social or biological factors.

If social factors mattered a lot I would expect parental attitudes to be significant in affecting transgender identity.

But most studies find low C. This holds even for population-based studies that do not suffer from ascertainment bias.

I would be surprised if peer influences were highly causal but parental influences were not.

I think the evidence from CAH, fraternal birth order effects, and animal models also provides good mechanistic reasons to think there are significant biological effects in E as well as A. How do trans people view this line of research?

They tend to hate it.

They're afraid it will eventually lead to 1.

Not choosing trans embryos during IVF.

2.

Aborting trans-fetuses.

3.

Lab by genetic testing to determine who is allowed to medically transition.

This is what I'll call medical eradication.

One half of the double bind.