Mike Israetel

speaker

1,094 appearances 5 recordings 5 series first heard Dec 2024 last heard May 2025

Mike Israetel’s voice in public audio — every appearance, attributed to the second.

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Mind Pump: Raw Fitness Truth · 2595: Mike Israetel Unplugged (Explicit Content) · 12 May 2025 podcast

You don't have a pump anymore. They say you're going up on stage. Whatever. It's fine. Competing is fine. And a lot of people love it. And I'm trying to get into the mode where I love it. But the thing I love most is improving my physique and eating the meals and getting the sleep and knowing that I have a purpose. And I treat my body as a sculpture and I'm always trying to improve it.

Am I going to be able to give that up? Yes. Do I want to give that up? Not really. Are there drugs already in the pipeline that are going to allow us with no anabolics whatsoever to radically go off?

fuckload of muscle and get super lean yes i could talk about those i'm waiting for them shits because when your boy gets his hands on that i'm going full send i want arms that are more inconvenient to live with now like now if i sleep on my side for long enough my arm goes dead because my delts and arms are big enough now the way it cut off their own circulation fellas i'm trying to get the whole shit i'm trying to get my arms amputated because they're so goddamn big that's when i've considered a fucking success

Is that body dysmorphia or not?

There's a drug that just passed primate trials and It's a dual antagonist. It antagonizes myostatin. Myostatin is the molecule that exists in all of your skeletal muscle that caps your muscle growth. Myo is muscle, statin is stopper or blocker. And the Latins really did figure all this shit out.

um basically that is a hugely powerful molecule that if you uncork you just fucking grow muscle all the time uh if you guys listen to this podcast google like double muscle mouse or muscle greyhound or muscle cow you're gonna see pictures that you're like what are they fucking what steroids are they feeding these things none and they don't train and they have as much muscle as physiologically possible given all their other genetics um

But there's more. There's another compound called activin A that also antagonizes muscle growth. And so this dual agonist, it antagonizes myostatin and alpha-activin. So these are blockers of muscle that these drugs uncork. They unblock. And the recent study that came out on these was, let me try to summarize the study really quick. So they had four groups of monkeys.

And they gave him all the fucking plague virus and they just released him into New York City. Wouldn't that be sweet? After outbreak with Dustin Hoffman back in the day, I've never seen research monkeys the same way. Keep them fucking demon monkeys the fuck away from me. However, so group number one, this is a 20-week diet they put these monkeys on, calorically restricted to a decent amount.

Group number one, they just did it natty, natty monkeys. You know, they're real proud of themselves and shit. They talk about how they're natty all the time in monkey language, but... The other monkeys, they just gave him semaglutide. So like, you know, like GLP-1, classic. The other group, they just gave him the myostatin inhibitor plus semaglutide.

And then the fourth group, they gave him the activin alpha, the activin A inhibitor, myostatin inhibitor plus semaglutide. So three fucking vectors. And what they found was the group number one, the natty monkeys, they lost almost no muscle and they lost a bit of fat. Group 2, the semaglutide monkeys, lost almost double the fat, but a significantly more muscle. Not a ton, but you can tell.

Group 3, that had the myostatin drug plus semaglutide, lost almost double the fat that the semaglutide monkeys lost. Almost triple the fat that the natty monkeys lost. And they lost about the same amount of muscle as the monkeys who were natty, which is to say almost none. So we're talking about a drug that you can lose like 2.7 times X the fat, but with zero added muscle loss. Check this out.

The triple monkeys, myostatin, activin, and semaglutide, they lost even more weight by a little bit. So basically three times the weight that the natty monkeys lost in fat. And they gained in muscle at the same time what the drug-free monkeys lost in fat. Wow. Wow. Wow. So let me put this really quick into common terms.

I translated these numbers into proxy for like a 200-pound person at 20% body fat. If the results hold for humans, which they'll similarly hold for humans, especially if you adjust the dosing. The natty human would be like two identical twins, one twin, 20% body fat. After 20 weeks, he's going to weigh 200 pounds, 20% body fat.

He's going to weigh about 192 pounds at about 16.5% fat, 20 weeks of dieting, drug-free. Cool, right? Cool. That's good. That's good, right? Janice at work notices and tries to suck your dick in the bathroom as usual. Yeah. And then, but you're at work. Janice, get the fuck away from me. I got shit to do.

And then the other identical twin, in this case, with the three drugs, started at 200 pounds, 20% body fat, in 20 weeks would have gotten to 181 pounds, which, okay, he lost like 10 more pounds, 11 more pounds, cool. 6.5% body fat. Wow. Wow. You guys, this is coming. Wow. It is only one of the drugs that Regeneron Pharmaceuticals is working on. It's already a drug. They already know it works.

It just has to go through FDA trials and don't you fucking bet against this. All the other pharmaceutical companies are catching on to that shit too because they realized semaglutide and all the GLP-1s and the GIP drugs that they have out now, they're unbelievable at helping people lose weight. The problem is people in a huge caloric deficit like that will lose some muscle.

And you can't have older women and older men Obese populations losing muscle because it tanks their metabolic health. It makes them fucking unable to take care of themselves. That's no good.

And so these companies have been working on these non-androgenic anabolics, these drugs that do nothing to do with steroids, no mood swings, no ball shrinkage, no yelling at your girlfriend and then crying afterwards and begging her not to leave. None of that shit. Some of it's fun, right? Trend is fun. It said no one ever. And then – So none of that, they just, these drugs are here.

And they, in several years, probably three years or less, depending on the FDA regulations, will be hitting the market. This will change everything. And I can't fucking wait because your boy's going to get fucking nonsense arms.

two percent of the people become insane and homicidal it's maybe just a chance i'm kidding oh god the ceo of regeneron's like getting you know i think all ceos have like one of those old revolvers in their desk that they take out to you know and and the whole thing when the stock goes down so that's what's happening um there's a reason that myostatin exists

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