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Mike Osterholm

👤 Person
279 total appearances

Appearances Over Time

Podcast Appearances

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And what happened was, as alpha gave way to beta, beta gave way to delta and the variants, and then we got to Omicron, we saw a very different impact on kids.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

But people had published these papers in the first year saying it's not a big risk for kids, that I don't get seriously ill.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And we missed totally what was changing with the epidemiology and pediatric COVID per the different variants.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And so the fact that, you know, 87% of the deaths occurred in year two and three,

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

We totally missed that.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

We were having all the arguments about school being open or closed or what we did based on what was from year one data.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And I think this was one of the lessons that taught us is you got to constantly be evaluating the data, whether it be for transmission purposes, for disease severity, et cetera.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And I think that's one of the lessons we should learn with these variants.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

These variants were really important.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And that was a newer picture issue.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

So, but I think that's the case.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

But in terms of your last point, unfortunately,

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

The only thing that's ever really going to take a pandemic off the table is having a global reach with vaccine, having access to everyone.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

That's an effective vaccine.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

And as you know, and I wrote in the book, I talked a lot about influenza because this is an area that I've been very involved with.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Right now, globally, we have the ability to make using chicken, egg and cell culture methods, the two we relied on for decades.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

We can make enough vaccine in one year if everything goes right to cover about a quarter of the world.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

It would take us three or more years to get enough vaccine for the world, which by that time, you know, the influenza pandemic could be over.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Now, where I had great hope, at least in the short term, I'd like to get that universal vaccine is mRNA technology.

Ground Truths
Mike Osterholm & Eric Topol - Discuss “The Big One” book

Because there, it wouldn't necessarily be any better vaccine for flu, meaning in terms of we know we have challenges with waning immunity with influenza vaccines.