Nick Norwitz

not only did it generate anxiety on behaviorally validated tests, but it was a transgenerational effect. So the offspring of the mice, and even the grand offspring... To epigenetic effects. Yeah, presumably.

not only did it generate anxiety on behaviorally validated tests, but it was a transgenerational effect. So the offspring of the mice, and even the grand offspring... To epigenetic effects. Yeah, presumably.

not only did it generate anxiety on behaviorally validated tests, but it was a transgenerational effect. So the offspring of the mice, and even the grand offspring... To epigenetic effects. Yeah, presumably.

So past, in this case, we're looking at the male lineage, but there was anxiety in the offspring and the grand offspring, even though they'd never been exposed to low-dose aspartame because their fathers and grandfathers had been exposed. So, you know, and...

So past, in this case, we're looking at the male lineage, but there was anxiety in the offspring and the grand offspring, even though they'd never been exposed to low-dose aspartame because their fathers and grandfathers had been exposed. So, you know, and...

So past, in this case, we're looking at the male lineage, but there was anxiety in the offspring and the grand offspring, even though they'd never been exposed to low-dose aspartame because their fathers and grandfathers had been exposed. So, you know, and...

There's, you know, physiologic explanations for how this might work, how aspartame also might affect brain health, how it's breaking down, how it changes amino acid transport to the brain. We can get all that. And also human data on, quote, say, irritability, including randomized controlled trials. So there's some signal in the human literature, for sure.

There's, you know, physiologic explanations for how this might work, how aspartame also might affect brain health, how it's breaking down, how it changes amino acid transport to the brain. We can get all that. And also human data on, quote, say, irritability, including randomized controlled trials. So there's some signal in the human literature, for sure.

There's, you know, physiologic explanations for how this might work, how aspartame also might affect brain health, how it's breaking down, how it changes amino acid transport to the brain. We can get all that. And also human data on, quote, say, irritability, including randomized controlled trials. So there's some signal in the human literature, for sure.

It's not the most rigorous of all time study, but then very concerning things in the preclinical literature. And the thing that people tend to do, the Diet Coke defenders, like a perverse Avengers or something, they tend to do is they put up a very implausible bar of evidence. So let's take the example of this study, this PNAS study.

It's not the most rigorous of all time study, but then very concerning things in the preclinical literature. And the thing that people tend to do, the Diet Coke defenders, like a perverse Avengers or something, they tend to do is they put up a very implausible bar of evidence. So let's take the example of this study, this PNAS study.

It's not the most rigorous of all time study, but then very concerning things in the preclinical literature. And the thing that people tend to do, the Diet Coke defenders, like a perverse Avengers or something, they tend to do is they put up a very implausible bar of evidence. So let's take the example of this study, this PNAS study.

What it's saying is in mammals, low-dose aspartame, the equivalent to what the FDA says is totally fine, it's like seven to 15% what the FDA says is okay, two to four eight ounce Diet Cokes can cause anxiety that is trans-generationally inheritable. You can ask, well, oh, prove this in humans.

What it's saying is in mammals, low-dose aspartame, the equivalent to what the FDA says is totally fine, it's like seven to 15% what the FDA says is okay, two to four eight ounce Diet Cokes can cause anxiety that is trans-generationally inheritable. You can ask, well, oh, prove this in humans.

What it's saying is in mammals, low-dose aspartame, the equivalent to what the FDA says is totally fine, it's like seven to 15% what the FDA says is okay, two to four eight ounce Diet Cokes can cause anxiety that is trans-generationally inheritable. You can ask, well, oh, prove this in humans.

I'm like, you're really gonna try to do a 50 to 60 year randomized controlled trial where you give human adults Diet Coke and then track, it's never gonna be done. And so you're asking for evidence that can't be collected. And I'm not saying the evidence is entirely watertight. So another paper just came out, and I think it was Cell Metabolism, on aspartame and cardiovascular disease.

I'm like, you're really gonna try to do a 50 to 60 year randomized controlled trial where you give human adults Diet Coke and then track, it's never gonna be done. And so you're asking for evidence that can't be collected. And I'm not saying the evidence is entirely watertight. So another paper just came out, and I think it was Cell Metabolism, on aspartame and cardiovascular disease.

I'm like, you're really gonna try to do a 50 to 60 year randomized controlled trial where you give human adults Diet Coke and then track, it's never gonna be done. And so you're asking for evidence that can't be collected. And I'm not saying the evidence is entirely watertight. So another paper just came out, and I think it was Cell Metabolism, on aspartame and cardiovascular disease.

And what they showed in mice, and also they had some monkey data, was that it can spike glucose and insulin. And what this did was increased plaque progression in susceptible mice, admittedly susceptible mice. However, the mechanism had to do with increasing certain molecules on the endothelial lining.

And what they showed in mice, and also they had some monkey data, was that it can spike glucose and insulin. And what this did was increased plaque progression in susceptible mice, admittedly susceptible mice. However, the mechanism had to do with increasing certain molecules on the endothelial lining.