Nick Norwitz

And I just want to emphasize one more thing, and then I'll get off my monologue. The really interesting thing about this population, lean mass hypersponders, is they are the first and only human population we have ever studied that has high LDL as an isolated variable, a

And I just want to emphasize one more thing, and then I'll get off my monologue. The really interesting thing about this population, lean mass hypersponders, is they are the first and only human population we have ever studied that has high LDL as an isolated variable, a

apart from metabolic dysfunction, because a lot of people are metabolically unhealthy in the population, and that changes the metabolic context, and apart from genetic drivers like familial hypercholesterolemia. So it's true if you have a broken lip metabolism. There are some people that are unlucky enough to be born with this.

apart from metabolic dysfunction, because a lot of people are metabolically unhealthy in the population, and that changes the metabolic context, and apart from genetic drivers like familial hypercholesterolemia. So it's true if you have a broken lip metabolism. There are some people that are unlucky enough to be born with this.

apart from metabolic dysfunction, because a lot of people are metabolically unhealthy in the population, and that changes the metabolic context, and apart from genetic drivers like familial hypercholesterolemia. So it's true if you have a broken lip metabolism. There are some people that are unlucky enough to be born with this.

If you have a broken lip metabolism, you can have very high LZL and also typically have advanced heart disease at an early age. Something called homozygous familial hypercholesterolemia. Kids will get heart attacks at like, you know, age... This is different because it's not that these people have broken liver metabolisms.

If you have a broken lip metabolism, you can have very high LZL and also typically have advanced heart disease at an early age. Something called homozygous familial hypercholesterolemia. Kids will get heart attacks at like, you know, age... This is different because it's not that these people have broken liver metabolisms.

If you have a broken lip metabolism, you can have very high LZL and also typically have advanced heart disease at an early age. Something called homozygous familial hypercholesterolemia. Kids will get heart attacks at like, you know, age... This is different because it's not that these people have broken liver metabolisms.

It's that in cutting out carbs, sometimes even irrespective of saturated fat intake, in cutting out carbs, there appears to be a metabolic response whereby the cholesterol trafficking, fat trafficking system gets upregulated. And as a result, an epiphenomenon, you could say the LDL goes through the roof.

It's that in cutting out carbs, sometimes even irrespective of saturated fat intake, in cutting out carbs, there appears to be a metabolic response whereby the cholesterol trafficking, fat trafficking system gets upregulated. And as a result, an epiphenomenon, you could say the LDL goes through the roof.

It's that in cutting out carbs, sometimes even irrespective of saturated fat intake, in cutting out carbs, there appears to be a metabolic response whereby the cholesterol trafficking, fat trafficking system gets upregulated. And as a result, an epiphenomenon, you could say the LDL goes through the roof.

So this is really a complex story that I'd love to get into with you about novel corners of physiology. resulting in pretty dramatic cholesterol lipid profiles that give most cardiologists heart attack by proxy. By that, I mean it's very shocking. And then examining, well, what's the mechanism behind this? And also, what does it mean for risk?

So this is really a complex story that I'd love to get into with you about novel corners of physiology. resulting in pretty dramatic cholesterol lipid profiles that give most cardiologists heart attack by proxy. By that, I mean it's very shocking. And then examining, well, what's the mechanism behind this? And also, what does it mean for risk?

So this is really a complex story that I'd love to get into with you about novel corners of physiology. resulting in pretty dramatic cholesterol lipid profiles that give most cardiologists heart attack by proxy. By that, I mean it's very shocking. And then examining, well, what's the mechanism behind this? And also, what does it mean for risk?

And these new data say the risk profile might not be what we would otherwise think if we weren't studying this population.

And these new data say the risk profile might not be what we would otherwise think if we weren't studying this population.

And these new data say the risk profile might not be what we would otherwise think if we weren't studying this population.

Right. So I think we're going to have to step back and go through some of the framing literature, but also make the critical point that some of the things you said that might sound at odds with what I said, like Apple being LDL being causative, are actually consistent with what I said.

Right. So I think we're going to have to step back and go through some of the framing literature, but also make the critical point that some of the things you said that might sound at odds with what I said, like Apple being LDL being causative, are actually consistent with what I said.

Right. So I think we're going to have to step back and go through some of the framing literature, but also make the critical point that some of the things you said that might sound at odds with what I said, like Apple being LDL being causative, are actually consistent with what I said.