Nick Norwitz

They said something to the effect of, why would you affiliate with these people who you don't share this perspective with? And I was so taken aback. I was like, really? Your expectations that I'd only collaborate and communicate with people who have a carbon copy of my perspective of the nutrition world? Isn't that a little dysfunctional? So we can differ on these things. I'm sharing my opinions.

They said something to the effect of, why would you affiliate with these people who you don't share this perspective with? And I was so taken aback. I was like, really? Your expectations that I'd only collaborate and communicate with people who have a carbon copy of my perspective of the nutrition world? Isn't that a little dysfunctional? So we can differ on these things. I'm sharing my opinions.

They said something to the effect of, why would you affiliate with these people who you don't share this perspective with? And I was so taken aback. I was like, really? Your expectations that I'd only collaborate and communicate with people who have a carbon copy of my perspective of the nutrition world? Isn't that a little dysfunctional? So we can differ on these things. I'm sharing my opinions.

They're evidence-based insofar as I'm reading the literature. But interpreting science is subjective. These are my two cents. You're free to hear other people's few cents and come to your own conclusion.

They're evidence-based insofar as I'm reading the literature. But interpreting science is subjective. These are my two cents. You're free to hear other people's few cents and come to your own conclusion.

They're evidence-based insofar as I'm reading the literature. But interpreting science is subjective. These are my two cents. You're free to hear other people's few cents and come to your own conclusion.

So there was a study that just came out in Cell Metabolism on how the sweetener aspartame can cause heart disease. I did use the word cause very intentionally. And that's because this was a mechanistic study. It was looking at how aspartame can promote heart disease progression. It was done in mice and monkeys. which comes with the caveats of animal studies.

So there was a study that just came out in Cell Metabolism on how the sweetener aspartame can cause heart disease. I did use the word cause very intentionally. And that's because this was a mechanistic study. It was looking at how aspartame can promote heart disease progression. It was done in mice and monkeys. which comes with the caveats of animal studies.

So there was a study that just came out in Cell Metabolism on how the sweetener aspartame can cause heart disease. I did use the word cause very intentionally. And that's because this was a mechanistic study. It was looking at how aspartame can promote heart disease progression. It was done in mice and monkeys. which comes with the caveats of animal studies.

But bear in mind, you can't do this study in humans. You can't do a randomized control trial where you say, here, you people, you're going to randomize you to a three-day protocol for 30 years and then check back in. You feasibly can't do this study. So you do need to turn to animal models to delve into mechanism and see how that lines with the human population data.

But bear in mind, you can't do this study in humans. You can't do a randomized control trial where you say, here, you people, you're going to randomize you to a three-day protocol for 30 years and then check back in. You feasibly can't do this study. So you do need to turn to animal models to delve into mechanism and see how that lines with the human population data.

But bear in mind, you can't do this study in humans. You can't do a randomized control trial where you say, here, you people, you're going to randomize you to a three-day protocol for 30 years and then check back in. You feasibly can't do this study. So you do need to turn to animal models to delve into mechanism and see how that lines with the human population data.

And human population data do suggest that artificial sweeteners associate with cardiovascular disease. So this gives mechanistic insight.

And human population data do suggest that artificial sweeteners associate with cardiovascular disease. So this gives mechanistic insight.

And human population data do suggest that artificial sweeteners associate with cardiovascular disease. So this gives mechanistic insight.

Now, what they did in this study is use different doses of aspartame, starting in mice who were vulnerable to cardiac disease, and showed that even at low doses, equivalent of about three Diet Cokes per day, we'll get back into that in a minute because there's been controversy over the dosing, but I'm going to say three Diet Cokes per day, cause plaque progression.

Now, what they did in this study is use different doses of aspartame, starting in mice who were vulnerable to cardiac disease, and showed that even at low doses, equivalent of about three Diet Cokes per day, we'll get back into that in a minute because there's been controversy over the dosing, but I'm going to say three Diet Cokes per day, cause plaque progression.

Now, what they did in this study is use different doses of aspartame, starting in mice who were vulnerable to cardiac disease, and showed that even at low doses, equivalent of about three Diet Cokes per day, we'll get back into that in a minute because there's been controversy over the dosing, but I'm going to say three Diet Cokes per day, cause plaque progression.

And what they found was that it contributed to insulin resistance, increased insulin levels. And what that led to was an increase in an adhesion molecule, CX3CL1. The name's not really important, but basically a molecular baseball glove for circulating immune cells, which then grabs the immune cells, brings them in to the artery wall, and that promotes plaque progression.

And what they found was that it contributed to insulin resistance, increased insulin levels. And what that led to was an increase in an adhesion molecule, CX3CL1. The name's not really important, but basically a molecular baseball glove for circulating immune cells, which then grabs the immune cells, brings them in to the artery wall, and that promotes plaque progression.