Nick Norwitz

And what they found was that it contributed to insulin resistance, increased insulin levels. And what that led to was an increase in an adhesion molecule, CX3CL1. The name's not really important, but basically a molecular baseball glove for circulating immune cells, which then grabs the immune cells, brings them in to the artery wall, and that promotes plaque progression.

So they showed this happened in mice, and then monkeys had a similar response, at least with respect to the insulin response to aspartame.

So they showed this happened in mice, and then monkeys had a similar response, at least with respect to the insulin response to aspartame.

So they showed this happened in mice, and then monkeys had a similar response, at least with respect to the insulin response to aspartame.

And it starts to build a case for, yeah, well, if we have an association between artificial sweetener intake, including aspartame and cardiovascular disease, and we have this mechanism which generalizes to primates, at least in some case, then what does this mean for cardiovascular health in humans? The data have their limitations. All studies do.

And it starts to build a case for, yeah, well, if we have an association between artificial sweetener intake, including aspartame and cardiovascular disease, and we have this mechanism which generalizes to primates, at least in some case, then what does this mean for cardiovascular health in humans? The data have their limitations. All studies do.

And it starts to build a case for, yeah, well, if we have an association between artificial sweetener intake, including aspartame and cardiovascular disease, and we have this mechanism which generalizes to primates, at least in some case, then what does this mean for cardiovascular health in humans? The data have their limitations. All studies do.

You will never have the RCT that some people are asking for. It's implausible. I present these data as food for thought so people can decide whether or not they want to have a Diet Coke. And, you know, Diet Coke being a common aspartame-containing food. And one thing I'll say is, like, you know, my perspective... is that the risk of eliminating a Diet Coke is negligible.

You will never have the RCT that some people are asking for. It's implausible. I present these data as food for thought so people can decide whether or not they want to have a Diet Coke. And, you know, Diet Coke being a common aspartame-containing food. And one thing I'll say is, like, you know, my perspective... is that the risk of eliminating a Diet Coke is negligible.

You will never have the RCT that some people are asking for. It's implausible. I present these data as food for thought so people can decide whether or not they want to have a Diet Coke. And, you know, Diet Coke being a common aspartame-containing food. And one thing I'll say is, like, you know, my perspective... is that the risk of eliminating a Diet Coke is negligible.

Zero, with respect to metabolic health. Like, if you don't have Diet Coke, nothing negative happens metabolically. It is totally a leisure item. And I also don't like the binary of people like, but is it worse than a Coke? I'm like... Probably not. But why set up that binary? People don't have a choice between just Coke and Diet Coke. You can have a water. You can have a sparkling water.

Zero, with respect to metabolic health. Like, if you don't have Diet Coke, nothing negative happens metabolically. It is totally a leisure item. And I also don't like the binary of people like, but is it worse than a Coke? I'm like... Probably not. But why set up that binary? People don't have a choice between just Coke and Diet Coke. You can have a water. You can have a sparkling water.

Zero, with respect to metabolic health. Like, if you don't have Diet Coke, nothing negative happens metabolically. It is totally a leisure item. And I also don't like the binary of people like, but is it worse than a Coke? I'm like... Probably not. But why set up that binary? People don't have a choice between just Coke and Diet Coke. You can have a water. You can have a sparkling water.

You can have a stevia sweetened beverage. So I'm not a fan of that binary. These are what the data said. And yes, people got very up in arms, very defensive. I mean, it's not really surprising. One guy did a hit piece on it that was kind of misleading, but he was being paid by the American Beverage Association. So that's not really surprising. They definitely have their tentacles everywhere.

You can have a stevia sweetened beverage. So I'm not a fan of that binary. These are what the data said. And yes, people got very up in arms, very defensive. I mean, it's not really surprising. One guy did a hit piece on it that was kind of misleading, but he was being paid by the American Beverage Association. So that's not really surprising. They definitely have their tentacles everywhere.

You can have a stevia sweetened beverage. So I'm not a fan of that binary. These are what the data said. And yes, people got very up in arms, very defensive. I mean, it's not really surprising. One guy did a hit piece on it that was kind of misleading, but he was being paid by the American Beverage Association. So that's not really surprising. They definitely have their tentacles everywhere.

At the end of the day, people make their own decisions, but those are what the data say. But I think it's socially fascinating to see how people tried to slice and undermine it. So going back to that three Diet Cokes per day thing. They don't say exactly how much fluid the mice consumed per day, but it was 0.15% aspartame. So there's different ways you can do the calculation.

At the end of the day, people make their own decisions, but those are what the data say. But I think it's socially fascinating to see how people tried to slice and undermine it. So going back to that three Diet Cokes per day thing. They don't say exactly how much fluid the mice consumed per day, but it was 0.15% aspartame. So there's different ways you can do the calculation.

At the end of the day, people make their own decisions, but those are what the data say. But I think it's socially fascinating to see how people tried to slice and undermine it. So going back to that three Diet Cokes per day thing. They don't say exactly how much fluid the mice consumed per day, but it was 0.15% aspartame. So there's different ways you can do the calculation.

In medical news today, the New York Post were both reporting three Diet Cokes per day based on their calculations, but they didn't show their math. So I showed my math, how do I get to that number, and came to a three Diet Cokes per day dose. Now, ironically, I actually made two math errors, but they balanced each other so that I redid the math. It comes out to about three Diet Cokes per day.