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Nick Norwitz

๐Ÿ‘ค Speaker
1350 total appearances

Appearances Over Time

Podcast Appearances

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

In medical news today, the New York Post were both reporting three Diet Cokes per day based on their calculations, but they didn't show their math. So I showed my math, how do I get to that number, and came to a three Diet Cokes per day dose. Now, ironically, I actually made two math errors, but they balanced each other so that I redid the math. It comes out to about three Diet Cokes per day.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

In medical news today, the New York Post were both reporting three Diet Cokes per day based on their calculations, but they didn't show their math. So I showed my math, how do I get to that number, and came to a three Diet Cokes per day dose. Now, ironically, I actually made two math errors, but they balanced each other so that I redid the math. It comes out to about three Diet Cokes per day.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Or, I mean, there's many different ways to do the math. One person was saying, oh, but you should do it based on body surface area, not adjustment for weight, because you want to adjust the mouse weight to human weight. And they came to 11 Diet Cokes per day. I'm like, okay, fine. Three, 11, it's besides the point.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Or, I mean, there's many different ways to do the math. One person was saying, oh, but you should do it based on body surface area, not adjustment for weight, because you want to adjust the mouse weight to human weight. And they came to 11 Diet Cokes per day. I'm like, okay, fine. Three, 11, it's besides the point.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Or, I mean, there's many different ways to do the math. One person was saying, oh, but you should do it based on body surface area, not adjustment for weight, because you want to adjust the mouse weight to human weight. And they came to 11 Diet Cokes per day. I'm like, okay, fine. Three, 11, it's besides the point.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And in fact, even at the lower dose of 0.5%, which would chop that 11 to a 3.66% dose, a 3.66% Diet Coke dose, there was still a biological effect. So the point here is, if you do try to dose adjust, there may be a physiologic response in humans. It's complicated by the fact that the human literature isn't really clear.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And in fact, even at the lower dose of 0.5%, which would chop that 11 to a 3.66% dose, a 3.66% Diet Coke dose, there was still a biological effect. So the point here is, if you do try to dose adjust, there may be a physiologic response in humans. It's complicated by the fact that the human literature isn't really clear.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

And in fact, even at the lower dose of 0.5%, which would chop that 11 to a 3.66% dose, a 3.66% Diet Coke dose, there was still a biological effect. So the point here is, if you do try to dose adjust, there may be a physiologic response in humans. It's complicated by the fact that the human literature isn't really clear.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Acute feeding studies in humans of aspartame don't necessarily show insulin spikes, but the literature is a little bit murky. Chronic feeding with artificial sweeteners does show an insulin resistance response in some people and not in others. So yeah, the human data is murky. I'm not saying this is a closed and shut deal.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Acute feeding studies in humans of aspartame don't necessarily show insulin spikes, but the literature is a little bit murky. Chronic feeding with artificial sweeteners does show an insulin resistance response in some people and not in others. So yeah, the human data is murky. I'm not saying this is a closed and shut deal.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

Acute feeding studies in humans of aspartame don't necessarily show insulin spikes, but the literature is a little bit murky. Chronic feeding with artificial sweeteners does show an insulin resistance response in some people and not in others. So yeah, the human data is murky. I'm not saying this is a closed and shut deal.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

But the new interesting mechanistic data, I think, and people can watch my video and see if it's reasonable, should make people think twice about having a Diet Coke. And at the end of the day, if they say, I really love Diet Coke, and a possible health negative consequence risk is worth it to me, then have a Diet Coke. You made an informed decision. Congratulations, you're an adult.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

But the new interesting mechanistic data, I think, and people can watch my video and see if it's reasonable, should make people think twice about having a Diet Coke. And at the end of the day, if they say, I really love Diet Coke, and a possible health negative consequence risk is worth it to me, then have a Diet Coke. You made an informed decision. Congratulations, you're an adult.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

But the new interesting mechanistic data, I think, and people can watch my video and see if it's reasonable, should make people think twice about having a Diet Coke. And at the end of the day, if they say, I really love Diet Coke, and a possible health negative consequence risk is worth it to me, then have a Diet Coke. You made an informed decision. Congratulations, you're an adult.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

That's where I stand. I'm not saying the data are conclusive be all end all. I'm just saying these are cool data. Think about them. I think they're compelling. I don't know if you read the paper, but what you thought, but that's where my stance is.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

That's where I stand. I'm not saying the data are conclusive be all end all. I'm just saying these are cool data. Think about them. I think they're compelling. I don't know if you read the paper, but what you thought, but that's where my stance is.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

That's where I stand. I'm not saying the data are conclusive be all end all. I'm just saying these are cool data. Think about them. I think they're compelling. I don't know if you read the paper, but what you thought, but that's where my stance is.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

A hundred percent. I stand by that as like a general rule of thumb. I don't care if people like have, you know, ice cream and grilled cheese for every meal and they're happy and healthy. Like at the end of the day, you do you and I will not judge you. I'm genuinely not like a judgmental person.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

A hundred percent. I stand by that as like a general rule of thumb. I don't care if people like have, you know, ice cream and grilled cheese for every meal and they're happy and healthy. Like at the end of the day, you do you and I will not judge you. I'm genuinely not like a judgmental person.

Dhru Purohit Show
This Study Shocks Cardiologists: LDL and ApoB May Not Predict Heart Disease Risk in Healthy People with Dr. Nick Norwitz

A hundred percent. I stand by that as like a general rule of thumb. I don't care if people like have, you know, ice cream and grilled cheese for every meal and they're happy and healthy. Like at the end of the day, you do you and I will not judge you. I'm genuinely not like a judgmental person.