Paul Saladino

We cannot make polyunsaturated fats. So we need a little bit. And historically as humans, we had a small amount of polyunsaturated fat in our diet, both as omega-3 and as omega-6. And omega-6 is the linoleic acid. Omega-3 is the kind of stuff you get from fish, generally speaking. Omega-6 and omega-3 have different pathways in the human body in terms of the downstream metabolites.

We'll talk about that also. But historically, we never had much omega-6. 1% of our calories. Today, 10% to 15% of our calories is omega-6. Some people have 20% of their calories as omega-6 fatty acids. So we have a historical... inconsistency here in what we're doing as humans. And that should raise the alarm. That should ask us, that should challenge us to ask questions.

We'll talk about that also. But historically, we never had much omega-6. 1% of our calories. Today, 10% to 15% of our calories is omega-6. Some people have 20% of their calories as omega-6 fatty acids. So we have a historical... inconsistency here in what we're doing as humans. And that should raise the alarm. That should ask us, that should challenge us to ask questions.

We'll talk about that also. But historically, we never had much omega-6. 1% of our calories. Today, 10% to 15% of our calories is omega-6. Some people have 20% of their calories as omega-6 fatty acids. So we have a historical... inconsistency here in what we're doing as humans. And that should raise the alarm. That should ask us, that should challenge us to ask questions.

But because of the cholesterol piece, because this lipid hypothesis has been at the center of medicine for so long, since the 1950s with Eisenhower, and we've been told that cholesterol causes heart disease, we have really, I think, been, we've been misled. And so the whole thing is kind of this house of cards, in my opinion. When you understand that cholesterol doesn't cause heart disease.

But because of the cholesterol piece, because this lipid hypothesis has been at the center of medicine for so long, since the 1950s with Eisenhower, and we've been told that cholesterol causes heart disease, we have really, I think, been, we've been misled. And so the whole thing is kind of this house of cards, in my opinion. When you understand that cholesterol doesn't cause heart disease.

But because of the cholesterol piece, because this lipid hypothesis has been at the center of medicine for so long, since the 1950s with Eisenhower, and we've been told that cholesterol causes heart disease, we have really, I think, been, we've been misled. And so the whole thing is kind of this house of cards, in my opinion. When you understand that cholesterol doesn't cause heart disease.

And this pisses people like Peter Attia off. And I would love to debate him on this, you know, because he really believes cholesterol does cause heart disease. All respect to Peter Attia, the whole house of cards falls. And so now let's just pause the seed oil conversation and I'll come back to that and I'll talk about cholesterol. You got any questions so far?

And this pisses people like Peter Attia off. And I would love to debate him on this, you know, because he really believes cholesterol does cause heart disease. All respect to Peter Attia, the whole house of cards falls. And so now let's just pause the seed oil conversation and I'll come back to that and I'll talk about cholesterol. You got any questions so far?

And this pisses people like Peter Attia off. And I would love to debate him on this, you know, because he really believes cholesterol does cause heart disease. All respect to Peter Attia, the whole house of cards falls. And so now let's just pause the seed oil conversation and I'll come back to that and I'll talk about cholesterol. You got any questions so far?

Okay. So cholesterol is a building block for steroid hormones in your body. Testosterone, estrogen, progesterone, aldosterone. These are all... built out of a cholesterol backbone. Cholesterol and triglycerides, which are fatty acids, are packaged into buses in your body that move these things around. One of those buses comes from the liver. It's called LDL, low density lipoprotein.

Okay. So cholesterol is a building block for steroid hormones in your body. Testosterone, estrogen, progesterone, aldosterone. These are all... built out of a cholesterol backbone. Cholesterol and triglycerides, which are fatty acids, are packaged into buses in your body that move these things around. One of those buses comes from the liver. It's called LDL, low density lipoprotein.

Okay. So cholesterol is a building block for steroid hormones in your body. Testosterone, estrogen, progesterone, aldosterone. These are all... built out of a cholesterol backbone. Cholesterol and triglycerides, which are fatty acids, are packaged into buses in your body that move these things around. One of those buses comes from the liver. It's called LDL, low density lipoprotein.

LDL contains a protein called ApoB100. ApoB containing lipoproteins are felt by Western medicine to be causal in atherosclerosis. Atherosclerosis is the process of plaque formation in your arteries of your heart, right? And I have a couple, I have a lot of problems with this theory. I think that they're close. I think Western medicine is close, but we're missing the mark.

LDL contains a protein called ApoB100. ApoB containing lipoproteins are felt by Western medicine to be causal in atherosclerosis. Atherosclerosis is the process of plaque formation in your arteries of your heart, right? And I have a couple, I have a lot of problems with this theory. I think that they're close. I think Western medicine is close, but we're missing the mark.

LDL contains a protein called ApoB100. ApoB containing lipoproteins are felt by Western medicine to be causal in atherosclerosis. Atherosclerosis is the process of plaque formation in your arteries of your heart, right? And I have a couple, I have a lot of problems with this theory. I think that they're close. I think Western medicine is close, but we're missing the mark.

And we're not seeing it because 90 plus percent of people are insulin resistant. And that'll make sense in a moment. So LDL is this lipoprotein particle. It has an ApoB 100 marker on it that says it's LDL. Other ApoB containing lipoproteins are things like VLDL, IDL, LP little a, chylomicron remnants, that's not terribly important for this conversation.

And we're not seeing it because 90 plus percent of people are insulin resistant. And that'll make sense in a moment. So LDL is this lipoprotein particle. It has an ApoB 100 marker on it that says it's LDL. Other ApoB containing lipoproteins are things like VLDL, IDL, LP little a, chylomicron remnants, that's not terribly important for this conversation.

And we're not seeing it because 90 plus percent of people are insulin resistant. And that'll make sense in a moment. So LDL is this lipoprotein particle. It has an ApoB 100 marker on it that says it's LDL. Other ApoB containing lipoproteins are things like VLDL, IDL, LP little a, chylomicron remnants, that's not terribly important for this conversation.

Just know that LDL is thought of as the bad cholesterol. And in most humans, when you eat saturated fat, LDL goes up. But if you look at the saturated fat literature, there was a study published in 2020 in the Journal of American College of Cardiology saying, hey, we looked at tons of studies, it's meta analysis. There's actually no real relationship between saturated fat and heart disease.