Paul Saladino

Just know that LDL is thought of as the bad cholesterol. And in most humans, when you eat saturated fat, LDL goes up. But if you look at the saturated fat literature, there was a study published in 2020 in the Journal of American College of Cardiology saying, hey, we looked at tons of studies, it's meta analysis. There's actually no real relationship between saturated fat and heart disease.

Just know that LDL is thought of as the bad cholesterol. And in most humans, when you eat saturated fat, LDL goes up. But if you look at the saturated fat literature, there was a study published in 2020 in the Journal of American College of Cardiology saying, hey, we looked at tons of studies, it's meta analysis. There's actually no real relationship between saturated fat and heart disease.

So that's the first problem here, is that saturated fat, which raises LDL, is not associated with heart disease. And some saturated fats, like 15 carbon and 17 carbon saturated fats, which occur in dairy, pentadecanoic acid and heptadecanoic acid are actually felt to be protective against cardiovascular disease. So there's lots of inconsistencies in the theory.

So that's the first problem here, is that saturated fat, which raises LDL, is not associated with heart disease. And some saturated fats, like 15 carbon and 17 carbon saturated fats, which occur in dairy, pentadecanoic acid and heptadecanoic acid are actually felt to be protective against cardiovascular disease. So there's lots of inconsistencies in the theory.

So that's the first problem here, is that saturated fat, which raises LDL, is not associated with heart disease. And some saturated fats, like 15 carbon and 17 carbon saturated fats, which occur in dairy, pentadecanoic acid and heptadecanoic acid are actually felt to be protective against cardiovascular disease. So there's lots of inconsistencies in the theory.

But you have LDL going up and mainstream medicine says LDL is causal, therefore the more LDL you have in your body, the more likely you are to get heart disease. but except when it doesn't, right? So if LDL is causal in heart disease, then why don't we get atherosclerosis in our veins and we only get it in our arteries? So veins are the vessels that your body uses to return blood to your heart.

But you have LDL going up and mainstream medicine says LDL is causal, therefore the more LDL you have in your body, the more likely you are to get heart disease. but except when it doesn't, right? So if LDL is causal in heart disease, then why don't we get atherosclerosis in our veins and we only get it in our arteries? So veins are the vessels that your body uses to return blood to your heart.

But you have LDL going up and mainstream medicine says LDL is causal, therefore the more LDL you have in your body, the more likely you are to get heart disease. but except when it doesn't, right? So if LDL is causal in heart disease, then why don't we get atherosclerosis in our veins and we only get it in our arteries? So veins are the vessels that your body uses to return blood to your heart.

arteries are moving away from your heart to your body. So I have a heart here. It pumps blood through my aorta. My aorta branches into all sorts of arteries. They go down my abdomen into my legs. So I have arteries moving blood from my lungs, which is oxygenated to my body, to my toes. And then in my toes, I have capillaries and then it turns into a vein. It comes back. So in arteries,

arteries are moving away from your heart to your body. So I have a heart here. It pumps blood through my aorta. My aorta branches into all sorts of arteries. They go down my abdomen into my legs. So I have arteries moving blood from my lungs, which is oxygenated to my body, to my toes. And then in my toes, I have capillaries and then it turns into a vein. It comes back. So in arteries,

arteries are moving away from your heart to your body. So I have a heart here. It pumps blood through my aorta. My aorta branches into all sorts of arteries. They go down my abdomen into my legs. So I have arteries moving blood from my lungs, which is oxygenated to my body, to my toes. And then in my toes, I have capillaries and then it turns into a vein. It comes back. So in arteries,

humans get atherosclerosis, but we do not get atherosclerosis in native veins. But there's the same amount of LDL circulating in all of these vessels. It's a continuous system. So why is that? Because arteries are higher pressure. And I would argue that you must have injury to the endothelial wall. That is often the beginning of atherosclerosis.

humans get atherosclerosis, but we do not get atherosclerosis in native veins. But there's the same amount of LDL circulating in all of these vessels. It's a continuous system. So why is that? Because arteries are higher pressure. And I would argue that you must have injury to the endothelial wall. That is often the beginning of atherosclerosis.

humans get atherosclerosis, but we do not get atherosclerosis in native veins. But there's the same amount of LDL circulating in all of these vessels. It's a continuous system. So why is that? Because arteries are higher pressure. And I would argue that you must have injury to the endothelial wall. That is often the beginning of atherosclerosis.

That is one of the proximate events of atherosclerosis. If LDL was causal, And the verbiage here is really, really important. If LDL is actually causing atherosclerosis, it should cause atherosclerosis in my veins. The assumption there is that LDL is somehow damaging to the endothelium, but we know that LDL that's not modified, not oxidized, doesn't damage the endothelium. It doesn't happen.

That is one of the proximate events of atherosclerosis. If LDL was causal, And the verbiage here is really, really important. If LDL is actually causing atherosclerosis, it should cause atherosclerosis in my veins. The assumption there is that LDL is somehow damaging to the endothelium, but we know that LDL that's not modified, not oxidized, doesn't damage the endothelium. It doesn't happen.

That is one of the proximate events of atherosclerosis. If LDL was causal, And the verbiage here is really, really important. If LDL is actually causing atherosclerosis, it should cause atherosclerosis in my veins. The assumption there is that LDL is somehow damaging to the endothelium, but we know that LDL that's not modified, not oxidized, doesn't damage the endothelium. It doesn't happen.

Atherosclerosis is a process by which LDL particles move into the sort of arterial wall. So in an artery, if you have like a tube and you cut the tube this way, or if you cut it lengthwise, and you look at the artery wall, you see there's an endothelium on the inside of the artery, and the LDL moves through the endothelium to this subendothelial space.

Atherosclerosis is a process by which LDL particles move into the sort of arterial wall. So in an artery, if you have like a tube and you cut the tube this way, or if you cut it lengthwise, and you look at the artery wall, you see there's an endothelium on the inside of the artery, and the LDL moves through the endothelium to this subendothelial space.

Atherosclerosis is a process by which LDL particles move into the sort of arterial wall. So in an artery, if you have like a tube and you cut the tube this way, or if you cut it lengthwise, and you look at the artery wall, you see there's an endothelium on the inside of the artery, and the LDL moves through the endothelium to this subendothelial space.