Paul Saladino

So there's more injuries to your endothelium, and the LDL particles are more likely to get stuck. When you eat more seed oils, which are these polyunsaturated fats, the LDL that gets stuck in the proteoglycan layer are more likely to oxidize. We know that for a fact.

So you have LDL that's more fragile, full of polyunsaturated fats, getting stuck to a proteoglycan matrix because you're insulin resistant. You're getting injury to the endothelial wall that we all get when we are... living our lives that doesn't get repaired because the insulin resistance impairs your immune function that repairs those endothelial walls. But LDL didn't cause any of that.

So you have LDL that's more fragile, full of polyunsaturated fats, getting stuck to a proteoglycan matrix because you're insulin resistant. You're getting injury to the endothelial wall that we all get when we are... living our lives that doesn't get repaired because the insulin resistance impairs your immune function that repairs those endothelial walls. But LDL didn't cause any of that.

So you have LDL that's more fragile, full of polyunsaturated fats, getting stuck to a proteoglycan matrix because you're insulin resistant. You're getting injury to the endothelial wall that we all get when we are... living our lives that doesn't get repaired because the insulin resistance impairs your immune function that repairs those endothelial walls. But LDL didn't cause any of that.

It's just getting caught up in the process. So this is the major problem with the theory for me is that there are plenty of examples of people with high LDL that don't get atherosclerosis or that don't get atherosclerosis at the rate that they should. And there are examples of people with low LDL who are insulin resistant who get lots of atherosclerosis.

It's just getting caught up in the process. So this is the major problem with the theory for me is that there are plenty of examples of people with high LDL that don't get atherosclerosis or that don't get atherosclerosis at the rate that they should. And there are examples of people with low LDL who are insulin resistant who get lots of atherosclerosis.

It's just getting caught up in the process. So this is the major problem with the theory for me is that there are plenty of examples of people with high LDL that don't get atherosclerosis or that don't get atherosclerosis at the rate that they should. And there are examples of people with low LDL who are insulin resistant who get lots of atherosclerosis.

So there are so many inconsistencies in the theory that I think what's going on here is we have conflated LDL as causal when it's actually just part of the causal cascade. So I'll just resume way out for people. I think about this like wood and fire. If you're going to build a campfire, you must have wood, right? You have to have wood, but wood didn't cause the fire. Right? Gotcha.

So there are so many inconsistencies in the theory that I think what's going on here is we have conflated LDL as causal when it's actually just part of the causal cascade. So I'll just resume way out for people. I think about this like wood and fire. If you're going to build a campfire, you must have wood, right? You have to have wood, but wood didn't cause the fire. Right? Gotcha.

So there are so many inconsistencies in the theory that I think what's going on here is we have conflated LDL as causal when it's actually just part of the causal cascade. So I'll just resume way out for people. I think about this like wood and fire. If you're going to build a campfire, you must have wood, right? You have to have wood, but wood didn't cause the fire. Right? Gotcha.

But wood also has other valuable things. If you get rid of the wood, you won't have any fire. You can lower someone's LDL and they will have less atherosclerosis, but that doesn't mean the LDL caused the atherosclerosis. If you lower wood, if you take away wood, if you have a forest that's been decimated by a forest fire, it's going to be hard to find wood to make a fire.

But wood also has other valuable things. If you get rid of the wood, you won't have any fire. You can lower someone's LDL and they will have less atherosclerosis, but that doesn't mean the LDL caused the atherosclerosis. If you lower wood, if you take away wood, if you have a forest that's been decimated by a forest fire, it's going to be hard to find wood to make a fire.

But wood also has other valuable things. If you get rid of the wood, you won't have any fire. You can lower someone's LDL and they will have less atherosclerosis, but that doesn't mean the LDL caused the atherosclerosis. If you lower wood, if you take away wood, if you have a forest that's been decimated by a forest fire, it's going to be hard to find wood to make a fire.

But that doesn't mean wood caused the fire. It was the lightning that caused the fire, right? You need the spark to cause the fire. So what's the spark? It's the insulin resistance.

But that doesn't mean wood caused the fire. It was the lightning that caused the fire, right? You need the spark to cause the fire. So what's the spark? It's the insulin resistance.

But that doesn't mean wood caused the fire. It was the lightning that caused the fire, right? You need the spark to cause the fire. So what's the spark? It's the insulin resistance.

It's the mitochondrial dysfunction leading to extra damage to the endothelial wall, leading to immune cell impairment, leading to LDL that's more likely to oxidize, leading to more proteoglycans in the matrix in the subendothelial space. The other thing, and where the metaphor extends, is that wood is also valuable. If you're living in the woods, you can build a house from wood.

It's the mitochondrial dysfunction leading to extra damage to the endothelial wall, leading to immune cell impairment, leading to LDL that's more likely to oxidize, leading to more proteoglycans in the matrix in the subendothelial space. The other thing, and where the metaphor extends, is that wood is also valuable. If you're living in the woods, you can build a house from wood.

It's the mitochondrial dysfunction leading to extra damage to the endothelial wall, leading to immune cell impairment, leading to LDL that's more likely to oxidize, leading to more proteoglycans in the matrix in the subendothelial space. The other thing, and where the metaphor extends, is that wood is also valuable. If you're living in the woods, you can build a house from wood.

In the human body, LDL is valuable. LDL serves an immune role. We've often been told LDL cholesterol is just there to kill us, which makes no sense evolutionarily. Sometimes you hear this explanation that like, we don't need LDL anymore because now we have antibiotics. But I think that's a little bit, that doesn't really jive with me. Historically,